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Literature DB >> 18502126

4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function.

Rajaneesh Anupam¹, Abhijit Nayek, Nicholas J Green, Frank J Grundy, Tina M Henkin, John A Means, Stephen C Bergmeier, Jennifer V Hines.

Abstract

The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18502126 PMCID： PMC2526248 DOI： 10.1016/j.bmcl.2008.05.015

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

35 in total

1. Monitoring uncharged tRNA during transcription of the Bacillus subtilis glyQS gene.

Authors: Frank J Grundy; Mary R Yousef; Tina M Henkin
Journal: J Mol Biol Date: 2004-12-15 Impact factor: 5.469

Review 2. Ions and RNA folding.

Authors: David E Draper; Dan Grilley; Ana Maria Soto
Journal: Annu Rev Biophys Biomol Struct Date: 2005

3. Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives.

Authors: Prasad P Dixit; Prathap S Nair; Vijaykumar J Patil; Sanjay Jain; Sudershan K Arora; Neelima Sinha
Journal: Bioorg Med Chem Lett Date: 2005-06-15 Impact factor: 2.823

4. Analysis of cis-acting sequence and structural elements required for antitermination of the Bacillus subtilis tyrS gene.

Authors: S M Rollins; F J Grundy; T M Henkin
Journal: Mol Microbiol Date: 1997-07 Impact factor: 3.501

5. Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA.

Authors: T Hermann; E Westhof
Journal: J Mol Biol Date: 1998-03-13 Impact factor: 5.469

6. Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A.

Authors: Folkert Reck; Fei Zhou; Marc Girardot; Gunther Kern; Charles J Eyermann; Neil J Hales; Rona R Ramsay; Michael B Gravestock
Journal: J Med Chem Date: 2005-01-27 Impact factor: 7.446

7. Fluorescence resonance energy transfer studies of aminoglycoside binding to a T box antiterminator RNA.

Authors: John A Means; Jennifer V Hines
Journal: Bioorg Med Chem Lett Date: 2005-04-15 Impact factor: 2.823

8. Inhibition of HIV-1 Tat-TAR interaction by diphenylfuran derivatives: effects of the terminal basic side chains.

Authors: N Gelus; C Bailly; F Hamy; T Klimkait; W D Wilson; D W Boykin
Journal: Bioorg Med Chem Date: 1999-06 Impact factor: 3.641

9. Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones.

Authors: Jagattaran Das; C V Laxman Rao; T V R S Sastry; M Roshaiah; P Gowri Sankar; Abdul Khadeer; M Sitaram Kumar; Arundhuti Mallik; N Selvakumar; Javed Iqbal; Sanjay Trehan
Journal: Bioorg Med Chem Lett Date: 2005-01-17 Impact factor: 2.823

10. Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors.

Authors: N B Matassova; M V Rodnina; R Endermann; H P Kroll; U Pleiss; H Wild; W Wintermeyer
Journal: RNA Date: 1999-07 Impact factor: 4.942

22 in total

1. Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles.

Authors: S Zhou; G Acquaah-Harrison; S C Bergmeier; J V Hines
Journal: Bioorg Med Chem Lett Date: 2011-09-29 Impact factor: 2.823

2. Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA.

Authors: Crina M Orac; Shu Zhou; John A Means; David Boehm; Stephen C Bergmeier; Jennifer V Hines
Journal: J Med Chem Date: 2011-08-31 Impact factor: 7.446

3. Conformational heterogeneity of the SAM-I riboswitch transcriptional ON state: a chaperone-like role for S-adenosyl methionine.

Authors: Wei Huang; Joohyun Kim; Shantenu Jha; Fareed Aboul-Ela
Journal: J Mol Biol Date: 2012-03-13 Impact factor: 5.469

4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function.

1. Monitoring uncharged tRNA during transcription of the Bacillus subtilis glyQS gene.

Review 2. Ions and RNA folding.

3. Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives.

4. Analysis of cis-acting sequence and structural elements required for antitermination of the Bacillus subtilis tyrS gene.

5. Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA.

6. Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A.

7. Fluorescence resonance energy transfer studies of aminoglycoside binding to a T box antiterminator RNA.

8. Inhibition of HIV-1 Tat-TAR interaction by diphenylfuran derivatives: effects of the terminal basic side chains.

9. Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones.

10. Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors.

1. Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles.

2. Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA.

3. Conformational heterogeneity of the SAM-I riboswitch transcriptional ON state: a chaperone-like role for S-adenosyl methionine.

4. Structure-activity studies of RNA-binding oxazolidinone derivatives.

Review 5. Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs.

6. Small molecule-RNA targeting: starting with the fundamentals.

7. RNA drug discovery: Conformational restriction enhances specific modulation of the T-box riboswitch function.

Review 8. An evolving tale of two interacting RNAs-themes and variations of the T-box riboswitch mechanism.

Review 9. The T box riboswitch: A novel regulatory RNA that utilizes tRNA as its ligand.

Review 10. The T box mechanism: tRNA as a regulatory molecule.