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Literature DB >> 21733684

Structure-activity studies of RNA-binding oxazolidinone derivatives.

Iwona Maciagiewicz¹, Shu Zhou, Stephen C Bergmeier, Jennifer V Hines.

Abstract

The structure-activity relationship of a series of oxazolidinones binding to T-box riboswitch antiterminator RNA has been investigated. Oxazolidinones differentially substituted at C-5 were prepared and the ligand-induced fluorescence resonance energy transfer (FRET) changes in FRET-labeled antiterminator model RNA were assayed. Both qualitative and quantitative analysis of the structure-activity relationship indicate that hydrogen bonding and hydrophobic properties play a significant role in ligand binding.

Entities: Chemical Gene Species

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Year: 2011 PMID： 21733684 PMCID： PMC3466080 DOI： 10.1016/j.bmcl.2011.05.130

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

18 in total

Review 1. Targeting RNA with small molecules.

Authors: Yitzhak Tor
Journal: Chembiochem Date: 2003-10-06 Impact factor: 3.164

2. Solution structure of the Bacillus subtilis T-box antiterminator RNA: seven nucleotide bulge characterized by stacking and flexibility.

Authors: Melinda S Gerdeman; Tina M Henkin; Jennifer V Hines
Journal: J Mol Biol Date: 2003-02-07 Impact factor: 5.469

3. Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.

Authors: Giuseppe Manfroni; Barbara Gatto; Oriana Tabarrini; Stefano Sabatini; Violetta Cecchetti; Giulia Giaretta; Cristina Parolin; Claudia Del Vecchio; Arianna Calistri; Manlio Palumbo; Arnaldo Fravolini
Journal: Bioorg Med Chem Lett Date: 2008-12-11 Impact factor: 2.823

Review 4. Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.

Authors: Ana Gutiérrez-Preciado; Tina M Henkin; Frank J Grundy; Charles Yanofsky; Enrique Merino
Journal: Microbiol Mol Biol Rev Date: 2009-03 Impact factor: 11.056

Review 5. Targeting RNA with small molecules.

Authors: Jason R Thomas; Paul J Hergenrother
Journal: Chem Rev Date: 2008-03-25 Impact factor: 60.622

Structure-activity studies of RNA-binding oxazolidinone derivatives.

Review 1. Targeting RNA with small molecules.

2. Solution structure of the Bacillus subtilis T-box antiterminator RNA: seven nucleotide bulge characterized by stacking and flexibility.

3. Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.

Review 4. Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.

Review 5. Targeting RNA with small molecules.

6. Structure-activity studies of oxazolidinone analogs as RNA-binding agents.

7. Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA.

8. 4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function.

9. Small molecule ligands for bulged RNA secondary structures.

10. Identification of neomycin B-binding site in T box antiterminator model RNA.

1. Basis for ligand discrimination between ON and OFF state riboswitch conformations: the case of the SAM-I riboswitch.

2. Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles.

3. Driving factors in amiloride recognition of HIV RNA targets.

4. Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA.

Review 5. Methods to enable the design of bioactive small molecules targeting RNA.

6. Small molecule-RNA targeting: starting with the fundamentals.

7. Ligand-induced changes in T box antiterminator RNA stability.

8. Factors that influence T box riboswitch efficacy and tRNA affinity.

9. Identification of Spermidine Binding Site in T-box Riboswitch Antiterminator RNA.

10. Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR.