| Literature DB >> 15603950 |
Jagattaran Das1, C V Laxman Rao, T V R S Sastry, M Roshaiah, P Gowri Sankar, Abdul Khadeer, M Sitaram Kumar, Arundhuti Mallik, N Selvakumar, Javed Iqbal, Sanjay Trehan.
Abstract
Some novel oxazolidinone derivatives with benzotriazole as pendant have been synthesized and tested for antibacterial activity. Linearly attached benzotriazole derivative showed more potency compared to angular one in vitro. Out of E/Z-isomers of angularly attached derivatives E-isomer was found to be more potent than Z-isomer. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. Finally, thioacetamide analogue of linear compound gave a lead having activity similar to linezolid in vitro.Entities:
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Year: 2005 PMID： 15603950 DOI： 10.1016/j.bmcl.2004.10.073
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823