Literature DB >> 18029195

A low-noise, wideband preamplifier for a Fourier-transform ion cyclotron resonance mass spectrometer.

Raman Mathur1, Ronald W Knepper, Peter B O'Connor.   

Abstract

FTMS performance parameters such as limits of detection, dynamic range, sensitivity, and even mass accuracy and resolution can be greatly improved by enhancing its detection circuit. An extended investigation of significant design considerations for optimal signal-to-noise ratio in an FTMS detection circuit are presented. A low noise amplifier for an FTMS is developed based on the discussed design rules. The amplifier has a gain of approximately 3500 and a bandwidth of 10 kHz to 1 MHz corresponding to m/z range of 100 Da to 10 kDa (at 7 Tesla). The performance of the amplifier was tested on a MALDI-FTMS, and has demonstrated a 25-fold reduction in noise in a mass spectrum of C(60) compared with that of a commercial amplifier.

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Year:  2007        PMID： 18029195      PMCID： PMC2872042          DOI： 10.1016/j.jasms.2007.09.013

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  10 in total

1.  Protein analysis by mass spectrometry and sequence database searching: tools for cancer research in the post-genomic era.

Authors:  S P Gygi; D K Han; A C Gingras; N Sonenberg; R Aebersold
Journal:  Electrophoresis       Date:  1999-02       Impact factor: 3.535

Review 2.  Mass spectrometry in proteomics.

Authors:  R Aebersold; D R Goodlett
Journal:  Chem Rev       Date:  2001-02       Impact factor: 60.622

3.  A high voltage RF oscillator for driving multipole ion guides.

Authors:  Peter B O'Connor; Catherine E Costello; William E Earle
Journal:  J Am Soc Mass Spectrom       Date:  2002-12       Impact factor: 3.109

4.  A high pressure matrix-assisted laser desorption ion source for Fourier transform mass spectrometry designed to accommodate large targets with diverse surfaces.

Authors:  Peter B O'Connor; Bogdan A Budnik; Vera B Ivleva; Parminder Kaur; Susanne C Moyer; Jason L Pittman; Catherine E Costello
Journal:  J Am Soc Mass Spectrom       Date:  2004-01       Impact factor: 3.109

5.  Use of statistical methods for estimation of total number of charges in a mass spectrometry experiment.

Authors:  Parminder Kaur; Peter B O'Connor
Journal:  Anal Chem       Date:  2004-05-15       Impact factor: 6.986

6.  A new hybrid electrospray Fourier transform mass spectrometer: design and performance characteristics.

Authors:  Peter B O'connor; Jason L Pittman; Bruce A Thomson; Bogdan A Budnik; Jason C Cournoyer; Judith Jebanathirajah; Cheng Lin; Susanne Moyer; Cheng Zhao
Journal:  Rapid Commun Mass Spectrom       Date:  2006       Impact factor: 2.419

7.  Routine Part-per-Million Mass Accuracy for High- Mass Ions:  Space-Charge Effects in MALDI FT-ICR.

Authors:  M L Easterling; T H Mize; I J Amster
Journal:  Anal Chem       Date:  1999-02-01       Impact factor: 6.986

8.  Use of mass spectrometric molecular weight information to identify proteins in sequence databases.

Authors:  M Mann; P Højrup; P Roepstorff
Journal:  Biol Mass Spectrom       Date:  1993-06

9.  Space charge effects in Fourier transform mass spectrometry. Mass calibration.

Authors:  E B Ledford; D L Rempel; M L Gross
Journal:  Anal Chem       Date:  1984-12       Impact factor: 6.986

10.  Proteomic analysis of the mammalian nuclear pore complex.

Authors:  Janet M Cronshaw; Andrew N Krutchinsky; Wenzhu Zhang; Brian T Chait; Michael J Matunis
Journal:  J Cell Biol       Date:  2002-08-26       Impact factor: 10.539
  10 in total
  6 in total

1.  A gain and bandwidth enhanced transimpedance preamplifier for Fourier-transform ion cyclotron resonance mass spectrometry.

Authors:  Tzu-Yung Lin; Roger J Green; Peter B O'Connor
Journal:  Rev Sci Instrum       Date:  2011-12       Impact factor: 1.523

2.  Artifacts in Fourier transform mass spectrometry.

Authors:  Raman Mathur; Peter B O'Connor
Journal:  Rapid Commun Mass Spectrom       Date:  2009-02       Impact factor: 2.419

3.  A low noise single-transistor transimpedance preamplifier for Fourier-transform mass spectrometry using a T feedback network.

Authors:  Tzu-Yung Lin; Roger J Green; Peter B O'Connor
Journal:  Rev Sci Instrum       Date:  2012-09       Impact factor: 1.523

4.  The spontaneous loss of coherence catastrophe in Fourier transform ion cyclotron resonance mass spectrometry.

Authors:  Konstantin Aizikov; Raman Mathur; Peter B O'Connor
Journal:  J Am Soc Mass Spectrom       Date:  2008-10-17       Impact factor: 3.109

5.  First signal on the cryogenic Fourier-transform ion cyclotron resonance mass spectrometer.

Authors:  Cheng Lin; Raman Mathur; Kostantin Aizikov; Peter B O'Connor
Journal:  J Am Soc Mass Spectrom       Date:  2007-09-14       Impact factor: 3.109

Review 6.  Developments in FTICR-MS and Its Potential for Body Fluid Signatures.

Authors:  Simone Nicolardi; Bogdan Bogdanov; André M Deelder; Magnus Palmblad; Yuri E M van der Burgt
Journal:  Int J Mol Sci       Date:  2015-11-13       Impact factor: 5.923
  6 in total

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