PURPOSE: X-ray angiography is currently the standard test for the assessment of coronary artery disease. A substantial minority of patients referred for coronary angiography have no significant coronary artery disease. The purpose of this work was the evaluation of the accuracy of a three-dimensional (3D) breathhold coronary magnetic resonance angiography (MRA) technique in detecting hemodynamically significant coronary artery stenoses in a patient population with x-ray angiographic correlation. MATERIALS AND METHODS: Sequential subjects (n = 33, M/F = 22/11, average age = 57) who were referred for conventional coronary angiography were enrolled in the study. The study protocol was approved by our institutional review board. Each subject gave written informed consent. Volume-targeted 3D breathhold coronary artery scans with ECG-triggered, segmented True Fast Imaging with Steady-state Precession (TrueFISP) were acquired for the left main (LM), left anterior descending (LAD), and right coronary arteries (RCAs). Coronary MRA was evaluated with conventional angiography as the gold standard. RESULTS: The overall sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) for diagnosing any hemodynamically significant coronary artery disease (> or =50% diameter reduction) with coronary MRA was 87%, 57%, 72%, 68%, and 80%, respectively. The sensitivity of the technique in the LM, LAD, and RCA was 100%, 83%, and 100%, respectively. The NPV of the technique in the LM, LAD, and RCA was 100%, 82%, and 100%, respectively. CONCLUSIONS: Three-dimensional breathhold True Fast Imaging with Steady-state Precession is a promising technique for coronary artery imaging. It has a relatively high sensitivity and NPV. Results of this study warrant further technical improvements and clinical evaluation of the technique.
PURPOSE: X-ray angiography is currently the standard test for the assessment of coronary artery disease. A substantial minority of patients referred for coronary angiography have no significant coronary artery disease. The purpose of this work was the evaluation of the accuracy of a three-dimensional (3D) breathhold coronary magnetic resonance angiography (MRA) technique in detecting hemodynamically significant coronary artery stenoses in a patient population with x-ray angiographic correlation. MATERIALS AND METHODS: Sequential subjects (n = 33, M/F = 22/11, average age = 57) who were referred for conventional coronary angiography were enrolled in the study. The study protocol was approved by our institutional review board. Each subject gave written informed consent. Volume-targeted 3D breathhold coronary artery scans with ECG-triggered, segmented True Fast Imaging with Steady-state Precession (TrueFISP) were acquired for the left main (LM), left anterior descending (LAD), and right coronary arteries (RCAs). Coronary MRA was evaluated with conventional angiography as the gold standard. RESULTS: The overall sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) for diagnosing any hemodynamically significant coronary artery disease (> or =50% diameter reduction) with coronary MRA was 87%, 57%, 72%, 68%, and 80%, respectively. The sensitivity of the technique in the LM, LAD, and RCA was 100%, 83%, and 100%, respectively. The NPV of the technique in the LM, LAD, and RCA was 100%, 82%, and 100%, respectively. CONCLUSIONS: Three-dimensional breathhold True Fast Imaging with Steady-state Precession is a promising technique for coronary artery imaging. It has a relatively high sensitivity and NPV. Results of this study warrant further technical improvements and clinical evaluation of the technique.
Authors: Jörg Barkhausen; Mathias Goyen; Stefan G Rühm; Holger Eggebrecht; Jörg F Debatin; Mark E Ladd Journal: AJR Am J Roentgenol Date: 2002-03 Impact factor: 3.959
Authors: Vibhas S Deshpande; Steven M Shea; Yiu Cho Chung; Richard M McCarthy; J Paul Finn; Debiao Li Journal: J Magn Reson Imaging Date: 2002-04 Impact factor: 4.813
Authors: W Y Kim; P G Danias; M Stuber; S D Flamm; S Plein; E Nagel; S E Langerak; O M Weber; E M Pedersen; M Schmidt; R M Botnar; W J Manning Journal: N Engl J Med Date: 2001-12-27 Impact factor: 91.245
Authors: Matthias Stuber; René M Botnar; Stefan E Fischer; Rolf Lamerichs; Jouke Smink; Paul Harvey; Warren J Manning Journal: Magn Reson Med Date: 2002-09 Impact factor: 4.668
Authors: Harald Kramer; Val M Runge; John N Morelli; Kenneth D Williams; L Gill Naul; Konstantin Nikolaou; Maximilian F Reiser; Bernd J Wintersperger Journal: Eur Radiol Date: 2011-04-09 Impact factor: 5.315
Authors: Jens Harald Kramer; Elisabeth Arnoldi; Christopher J François; Andrew L Wentland; Konstantin Nikolaou; Bernd J Wintersperger; Thomas M Grist Journal: Invest Radiol Date: 2013-03 Impact factor: 6.016
Authors: Giovanni Di Leo; Erica Fisci; Francesco Secchi; Marco Alì; Federico Ambrogi; Luca Maria Sconfienza; Francesco Sardanelli Journal: Eur Radiol Date: 2015-12-11 Impact factor: 5.315