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Literature DB >> 1719545

A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.

D R Burton¹, C F Barbas, M A Persson, S Koenig, R M Chanock, R A Lerner.

Abstract

A panel of human monoclonal antibody Fab fragments has been generated against the surface glycoprotein gp120 of type 1 human immunodeficiency virus (HIV) by antigen selection from a random combinatorial library expressed on the surface of filamentous phage. The library was prepared from 5 ml of bone marrow from an asymptomatic individual who has been HIV-positive for 6 years. The antibodies have high affinity for antigen (mostly with affinity constants of greater than 10(8) M-1) and notable sequence diversity. Given appropriate donor selection, the methods described should allow the generation of antibodies for the evaluation of passive immunization as a therapy for AIDS.

Entities: Disease Species

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Year: 1991 PMID： 1719545 PMCID： PMC52882 DOI： 10.1073/pnas.88.22.10134

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

Review 1. Genomic diversity and antigenic variation of HIV-1: links between pathogenesis, epidemiology and vaccine development.

Authors: J Goudsmit; N K Back; P L Nara
Journal: FASEB J Date: 1991-07 Impact factor: 5.191

Review 2. Neutralization of HIV-1: a paradox of humoral proportions.

Authors: P L Nara; R R Garrity; J Goudsmit
Journal: FASEB J Date: 1991-07 Impact factor: 5.191

3. Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

Authors: C F Barbas; A S Kang; R A Lerner; S J Benkovic
Journal: Proc Natl Acad Sci U S A Date: 1991-09-15 Impact factor: 11.205

4. Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

Authors: A S Kang; C F Barbas; K D Janda; S J Benkovic; R A Lerner
Journal: Proc Natl Acad Sci U S A Date: 1991-05-15 Impact factor: 11.205

Review 5. Man-made antibodies.

Authors: G Winter; C Milstein
Journal: Nature Date: 1991-01-24 Impact factor: 49.962

6. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors: P Chomczynski; N Sacchi
Journal: Anal Biochem Date: 1987-04 Impact factor: 3.365

7. Vaccine protection against HIV-2 infection in cynomolgus monkeys.

Authors: P Putkonen; R Thorstensson; L Walther; J Albert; L Akerblom; O Granquist; G Wadell; E Norrby; G Biberfeld
Journal: AIDS Res Hum Retroviruses Date: 1991-03 Impact factor: 2.205

8. Making antibody fragments using phage display libraries.

Authors: T Clackson; H R Hoogenboom; A D Griffiths; G Winter
Journal: Nature Date: 1991-08-15 Impact factor: 49.962

9. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes.

Authors: S F Parmley; G P Smith
Journal: Gene Date: 1988-12-20 Impact factor: 3.688

Review 10. Human and mouse monoclonal antibodies by repertoire cloning.

Authors: D R Burton
Journal: Trends Biotechnol Date: 1991-05 Impact factor: 19.536

252 in total

1. Ebola virus can be effectively neutralized by antibody produced in natural human infection.

Authors: T Maruyama; L L Rodriguez; P B Jahrling; A Sanchez; A S Khan; S T Nichol; C J Peters; P W Parren; D R Burton
Journal: J Virol Date: 1999-07 Impact factor: 5.103

Review 2. Generation of recombinant antibodies.

Authors: S M Kipriyanov; M Little
Journal: Mol Biotechnol Date: 1999-09 Impact factor: 2.695

3. CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells.

Authors: I I Singer; S Scott; D W Kawka; J Chin; B L Daugherty; J A DeMartino; J DiSalvo; S L Gould; J E Lineberger; L Malkowitz; M D Miller; L Mitnaul; S J Siciliano; M J Staruch; H R Williams; H J Zweerink; M S Springer
Journal: J Virol Date: 2001-04 Impact factor: 5.103

4. Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope protein.

Authors: Terri G Edwards; Stéphanie Wyss; Jacqueline D Reeves; Susan Zolla-Pazner; James A Hoxie; Robert W Doms; Frédéric Baribaud
Journal: J Virol Date: 2002-03 Impact factor: 5.103

5. Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design.

Authors: Ralph Pantophlet; Ian A Wilson; Dennis R Burton
Journal: J Virol Date: 2003-05 Impact factor: 5.103

6. Modified cytokeratins expressed on the surface of carcinoma cells undergo endocytosis upon binding of human monoclonal antibody and its recombinant Fab fragment.

Authors: H J Ditzel; U Garrigues; C B Andersen; M K Larsen; H J Garrigues; A Svejgaard; I Hellström; K E Hellström; J C Jensenius
Journal: Proc Natl Acad Sci U S A Date: 1997-07-22 Impact factor: 11.205