Literature DB >> 1987490

Man-made antibodies.

G Winter1, C Milstein.   

Abstract

Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extended to production of 'in vitro' repertoires of variable domain genes, and obviate the immunization of animals?

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Year:  1991        PMID： 1987490     DOI： 10.1038/349293a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  157 in total

Review 1.  Immunomodulation of autoimmune responses with monoclonal antibodies and immunoadhesins: treatment of ocular inflammatory disease in the next millennium.

Authors:  A D Dick; J D Isaacs
Journal:  Br J Ophthalmol       Date:  1999-11       Impact factor: 4.638

Review 2.  Molecular therapy in ocular wound healing.

Authors:  M F Cordeiro; G S Schultz; R R Ali; S S Bhattacharya; P T Khaw
Journal:  Br J Ophthalmol       Date:  1999-11       Impact factor: 4.638

3.  A human myeloma cell line suitable for the generation of human monoclonal antibodies.

Authors:  A Karpas; A Dremucheva; B H Czepulkowski
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

4.  Kinetics of association of anti-lysozyme monoclonal antibody D44.1 and hen-egg lysozyme.

Authors:  G Altobelli; S Subramaniam
Journal:  Biophys J       Date:  2000-12       Impact factor: 4.033

5.  By-passing selection: direct screening for antibody-antigen interactions using protein arrays.

Authors:  L J Holt; K Büssow; G Walter; I M Tomlinson
Journal:  Nucleic Acids Res       Date:  2000-08-01       Impact factor: 16.971

6.  Continuous affinity-based selection: rapid screening and simultaneous amplification of bacterial surface-display libraries.

Authors:  D Patel; S Vitovski; H J Senior; M D Edge; R C Hockney; M J Dempsey; J R Sayers
Journal:  Biochem J       Date:  2001-08-01       Impact factor: 3.857

Review 7.  'Molecular farming' of antibodies in plants.

Authors:  Stefan Schillberg; Rainer Fischer; Neil Emans
Journal:  Naturwissenschaften       Date:  2003-02-18

8.  Regulated secretion and purification of recombinant antibodies in E. coli.

Authors:  S Dübel; F Breitling; I Klewinghaus; M Little
Journal:  Cell Biophys       Date:  1992 Aug-Dec

Review 9.  Recombinant human monoclonal antibodies. Basic principles of the immune system transferred to E. coli.

Authors:  P Fuchs; S Dübel; F Breitling; M Braunagel; I Klewinghaus; M Little
Journal:  Cell Biophys       Date:  1992 Aug-Dec

10.  Hybridoma-free generation of monoclonal antibodies.

Authors:  Renata Pasqualini; Wadih Arap
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-19       Impact factor: 11.205
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