Literature DB >> 1367284

Human and mouse monoclonal antibodies by repertoire cloning.

D R Burton1.   

Abstract

Antibody repertoires, the wide range of antibody molecules produced by animals, can now be established in bacteria by cloning and expression of antibody genes. Beginning with immunized animals, antigen can be used to select, from the repertoire, clones which secrete specific monoclonal antibody. In the future, immunization may become unnecessary. The method may provide a general route, which has so far eluded biotechnologists, to human monoclonal antibodies.

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Year:  1991        PMID： 1367284     DOI： 10.1016/0167-7799(91)90055-m

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  5 in total

1.  On the use of combinatorial antibody libraries to clone the "fossil record" of an individual's immune response.

Authors:  R A Lerner; C F Barbas; A S Kang; D R Burton
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

2.  Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

Authors:  C F Barbas; A S Kang; R A Lerner; S J Benkovic
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-15       Impact factor: 11.205

3.  The rescue by phage display of human Fabs to gp120 HIV-1 glycoprotein using EBV transformed lymphocytes.

Authors:  E Kempf; E Weiss; P Klein; A Glacet; S Spratt; D Bourel; G Orfanoudakis
Journal:  Mol Biotechnol       Date:  2001-02       Impact factor: 2.695

4.  A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.

Authors:  D R Burton; C F Barbas; M A Persson; S Koenig; R M Chanock; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

5.  Antibody fragments from a 'single pot' phage display library as immunochemical reagents.

Authors:  A Nissim; H R Hoogenboom; I M Tomlinson; G Flynn; C Midgley; D Lane; G Winter
Journal:  EMBO J       Date:  1994-02-01       Impact factor: 11.598
  5 in total

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