Thilo Schimitzek1, Michael Bach. 1. Eye Department, Arrowe Park Hospital, Arrowe Park Road, Upton, Wirral, Merseyside, CH49 5PE, UK.
Abstract
PURPOSE: To assess the efficacy of high luminance in increasing the amplitude of the multifocal electroretinogram (mfERG). We examined 5 male and 5 female volunteers in the age of 22-52 years (median 28 years). Three different stimulus luminance levels were applied: the bright areas of the stimulus pattern were set to 150, 300 and 500 cd/m(2). We recorded the potentials via DTL electrodes using the VERIS Science 4.4 system with 61 hexagons, pupils were dilated. Analysis was based on the 5 ring averages. RESULTS: Across all hexagons and subjects, the response density (approximately amplitude) rose by 20% when increasing the luminance by a factor of 3.3. The peak times decreased slightly with higher luminance, by less then 1.5 ms. CONCLUSIONS: Combining the present results with those from two previous studies, the gain (= relative amplitude increase for relative luminance increase) is close to 0.4 over a range of 56-700 cd/m(2). The stimulus luminance range suggested in the mfERG guidelines seems well chosen.
PURPOSE: To assess the efficacy of high luminance in increasing the amplitude of the multifocal electroretinogram (mfERG). We examined 5 male and 5 female volunteers in the age of 22-52 years (median 28 years). Three different stimulus luminance levels were applied: the bright areas of the stimulus pattern were set to 150, 300 and 500 cd/m(2). We recorded the potentials via DTL electrodes using the VERIS Science 4.4 system with 61 hexagons, pupils were dilated. Analysis was based on the 5 ring averages. RESULTS: Across all hexagons and subjects, the response density (approximately amplitude) rose by 20% when increasing the luminance by a factor of 3.3. The peak times decreased slightly with higher luminance, by less then 1.5 ms. CONCLUSIONS: Combining the present results with those from two previous studies, the gain (= relative amplitude increase for relative luminance increase) is close to 0.4 over a range of 56-700 cd/m(2). The stimulus luminance range suggested in the mfERG guidelines seems well chosen.
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