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Literature DB >> 16990789

Back to the future: education for systems-level biologists.

Abstract

We describe a graduate course in quantitative biology that is based on original path-breaking papers in diverse areas of biology; each of these papers depends on quantitative reasoning and theory as well as experiment. Close reading and discussion of these papers allows students with backgrounds in physics, computational sciences or biology to learn essential ideas and to communicate in the languages of disciplines other than their own.

Mesh：

Year: 2006 PMID： 16990789 PMCID： PMC1950154 DOI： 10.1038/nrm2023

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

14 in total

1. Stochastic gene expression in a single cell.

Authors: Michael B Elowitz; Arnold J Levine; Eric D Siggia; Peter S Swain
Journal: Science Date: 2002-08-16 Impact factor: 47.728

2. Introductory science and mathematics education for 21st-Century biologists.

Authors: William Bialek; David Botstein
Journal: Science Date: 2004-02-06 Impact factor: 47.728

3. Multistability in the lactose utilization network of Escherichia coli.

Authors: Ertugrul M Ozbudak; Mukund Thattai; Han N Lim; Boris I Shraiman; Alexander Van Oudenaarden
Journal: Nature Date: 2004-02-19 Impact factor: 49.962

4. ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON.

Authors: A Novick; M Weiner
Journal: Proc Natl Acad Sci U S A Date: 1957-07-15 Impact factor: 11.205

5. Mutations of Bacteria from Virus Sensitivity to Virus Resistance.

Authors: S E Luria; M Delbrück
Journal: Genetics Date: 1943-11 Impact factor: 4.562

6. Robustness in simple biochemical networks.

Authors: N Barkai; S Leibler
Journal: Nature Date: 1997-06-26 Impact factor: 49.962

7. Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity.

Authors: J J Hopfield
Journal: Proc Natl Acad Sci U S A Date: 1974-10 Impact factor: 11.205

8. An amplified sensitivity arising from covalent modification in biological systems.

Authors: A Goldbeter; D E Koshland
Journal: Proc Natl Acad Sci U S A Date: 1981-11 Impact factor: 11.205

9. A phylogenomic study of the MutS family of proteins.

Authors: J A Eisen
Journal: Nucleic Acids Res Date: 1998-09-15 Impact factor: 16.971

10. Cluster analysis and display of genome-wide expression patterns.

Authors: M B Eisen; P T Spellman; P O Brown; D Botstein
Journal: Proc Natl Acad Sci U S A Date: 1998-12-08 Impact factor: 11.205

11 in total

1. Discovering New Biology through Sequencing of RNA.

Authors: Andreas P M Weber
Journal: Plant Physiol Date: 2015-09-09 Impact factor: 8.340

2. Building the next generation of quantitative biologists.

Authors: Kristine A Pattin; Anna C Greene; Russ B Altman; Lawrence E Hunter; David A Ross; James A Foster; Jason H Moore
Journal: Pac Symp Biocomput Date: 2014

Review 3. Bridging the gaps in systems biology.

Authors: Marija Cvijovic; Joachim Almquist; Jonas Hagmar; Stefan Hohmann; Hans-Michael Kaltenbach; Edda Klipp; Marcus Krantz; Pedro Mendes; Sven Nelander; Jens Nielsen; Andrea Pagnani; Natasa Przulj; Andreas Raue; Jörg Stelling; Szymon Stoma; Frank Tobin; Judith A H Wodke; Riccardo Zecchina; Mats Jirstrand
Journal: Mol Genet Genomics Date: 2014-04-13 Impact factor: 3.291

4. The Next Generation of Training for Arabidopsis Researchers: Bioinformatics and Quantitative Biology.

Authors: Joanna Friesner; Sarah M Assmann; Ruth Bastow; Julia Bailey-Serres; Jim Beynon; Volker Brendel; C Robin Buell; Alexander Bucksch; Wolfgang Busch; Taku Demura; Jose R Dinneny; Colleen J Doherty; Andrea L Eveland; Pascal Falter-Braun; Malia A Gehan; Michael Gonzales; Erich Grotewold; Rodrigo Gutierrez; Ute Kramer; Gabriel Krouk; Shisong Ma; R J Cody Markelz; Molly Megraw; Blake C Meyers; James A H Murray; Nicholas J Provart; Sue Rhee; Roger Smith; Edgar P Spalding; Crispin Taylor; Tracy K Teal; Keiko U Torii; Chris Town; Matthew Vaughn; Richard Vierstra; Doreen Ware; Olivia Wilkins; Cranos Williams; Siobhan M Brady
Journal: Plant Physiol Date: 2017-12 Impact factor: 8.340

10. A proposed minimum skill set for university graduates to meet the informatics needs and challenges of the "-omics" era.

Authors: Tin Wee Tan; Shen Jean Lim; Asif M Khan; Shoba Ranganathan
Journal: BMC Genomics Date: 2009-12-03 Impact factor: 3.969