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Literature DB >> 6947258

An amplified sensitivity arising from covalent modification in biological systems.

Abstract

The transient and steady-state behavior of a reversible covalent modification system is examined. When the modifying enzymes operate outside the region of first-order kinetics, small percentage changes in the concentration of the effector controlling either of the modifying enzymes can give much larger percentage changes in the amount of modified protein. This amplification of the response to a stimulus can provide additional sensitivity in biological control, equivalent to that of allosteric proteins with high Hill coefficients.

Mesh：

Substances：
Proteins

Year: 1981 PMID： 6947258 PMCID： PMC349147 DOI： 10.1073/pnas.78.11.6840

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. Superiority of interconvertible enzyme cascades in metabolite regulation: analysis of multicyclic systems.

Authors: P B Chock; E R Stadtman
Journal: Proc Natl Acad Sci U S A Date: 1977-07 Impact factor: 11.205

2. The phosphorylase b to a converting enzyme of rabbit skeletal muscle.

Authors: E G KREBS; E H FISCHER
Journal: Biochim Biophys Acta Date: 1956-04

3. Protein kinase activity associated with the avian sarcoma virus src gene product.

Authors: M S Collett; R L Erikson
Journal: Proc Natl Acad Sci U S A Date: 1978-04 Impact factor: 11.205

Review 4. Interconvertible enzyme cascades in metabolic regulation.

Authors: E R Stadtman; P B Chock
Journal: Curr Top Cell Regul Date: 1978

Review 5. Phosphorylation-dephosphorylation of enzymes.

Authors: E G Krebs; J A Beavo
Journal: Annu Rev Biochem Date: 1979 Impact factor: 23.643

Review 6. A model regulatory system: bacterial chemotaxis.

Authors: D E Koshland
Journal: Physiol Rev Date: 1979-10 Impact factor: 37.312

Review 7. Regulation of oxygen affinity of hemoglobin: influence of structure of the globin on the heme iron.

Authors: M F Perutz
Journal: Annu Rev Biochem Date: 1979 Impact factor: 23.643

Review 8. Protein methylation in behavioural control mechanisms and in signal transduction.

Authors: M S Springer; M F Goy; J Adler
Journal: Nature Date: 1979-07-26 Impact factor: 49.962

9. The sequential inactivation of glycogen phosphorylase and activation of glycogen synthetase in liver after the administration of glucose to mice and rats. The mechanism of the hepatic threshold to glucose.

Authors: W Stalmans; H De Wulf; L Hue; H G Hers
Journal: Eur J Biochem Date: 1974-01-03

Review 10. The phosphoprotein phosphatases: properties of the enzymes involved in the regulation of glycogen metabolism.

Authors: E Y Lee; S R Silberman; M K Ganapathi; S Petrović; H Paris
Journal: Adv Cyclic Nucleotide Res Date: 1980

409 in total

1. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties.

Authors: A Levchenko; J Bruck; P W Sternberg
Journal: Proc Natl Acad Sci U S A Date: 2000-05-23 Impact factor: 11.205

An amplified sensitivity arising from covalent modification in biological systems.

1. Superiority of interconvertible enzyme cascades in metabolite regulation: analysis of multicyclic systems.

2. The phosphorylase b to a converting enzyme of rabbit skeletal muscle.

3. Protein kinase activity associated with the avian sarcoma virus src gene product.

Review 4. Interconvertible enzyme cascades in metabolic regulation.

Review 5. Phosphorylation-dephosphorylation of enzymes.

Review 6. A model regulatory system: bacterial chemotaxis.

Review 7. Regulation of oxygen affinity of hemoglobin: influence of structure of the globin on the heme iron.

Review 8. Protein methylation in behavioural control mechanisms and in signal transduction.

9. The sequential inactivation of glycogen phosphorylase and activation of glycogen synthetase in liver after the administration of glucose to mice and rats. The mechanism of the hepatic threshold to glucose.

Review 10. The phosphoprotein phosphatases: properties of the enzymes involved in the regulation of glycogen metabolism.

1. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties.

2. Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation.

Review 3. Model scenarios for evolution of the eukaryotic cell cycle.

4. Fluctuations in repressor control: thermodynamic constraints on stochastic focusing.

5. Modeling the fission yeast cell cycle: quantized cycle times in wee1- cdc25Delta mutant cells.

6. Testing a mathematical model of the yeast cell cycle.

7. Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils.

8. Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades.

9. Attenuation of noise in ultrasensitive signaling cascades.

10. Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated.