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Literature DB >> 16942631

Fast, cheap and somewhat in control.

Abstract

Efforts to manipulate living organisms have raised the question of whether engineering principles of hierarchy, abstraction and design can be applied to biological systems. Here, we consider the practical challenges to controlling living organisms that must be surmounted, or at least managed, if synthetic biology and cellular bioengineering are to be productive.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2006 PMID： 16942631 PMCID： PMC1779602 DOI： 10.1186/gb-2006-7-8-114

Source DB: PubMed Journal: Genome Biol ISSN： 1474-7596 Impact factor: 13.583

33 in total

1. Intrinsic and extrinsic contributions to stochasticity in gene expression.

Authors: Peter S Swain; Michael B Elowitz; Eric D Siggia
Journal: Proc Natl Acad Sci U S A Date: 2002-09-17 Impact factor: 11.205

2. Control of stochasticity in eukaryotic gene expression.

Authors: Jonathan M Raser; Erin K O'Shea
Journal: Science Date: 2004-05-27 Impact factor: 47.728

Review 3. Reconstruction of genetic circuits.

Authors: David Sprinzak; Michael B Elowitz
Journal: Nature Date: 2005-11-24 Impact factor: 49.962

4. Stochastic amplification and signaling in enzymatic futile cycles through noise-induced bistability with oscillations.

Authors: Michael Samoilov; Sergey Plyasunov; Adam P Arkin
Journal: Proc Natl Acad Sci U S A Date: 2005-02-08 Impact factor: 11.205

5. Phenotypic diversity, population growth, and information in fluctuating environments.

Authors: Edo Kussell; Stanislas Leibler
Journal: Science Date: 2005-08-25 Impact factor: 47.728

Review 6. Expanding the genetic code.

Authors: Lei Wang; Jianming Xie; Peter G Schultz
Journal: Annu Rev Biophys Biomol Struct Date: 2006

7. Stochastic protein expression in individual cells at the single molecule level.

Authors: Long Cai; Nir Friedman; X Sunney Xie
Journal: Nature Date: 2006-03-16 Impact factor: 49.962

8. Single-nutrient microbial competition: qualitative agreement between experimental and theoretically forecast outcomes.

Authors: S R Hansen; S P Hubbell
Journal: Science Date: 1980-03-28 Impact factor: 47.728

10. Temperature control of fimbriation circuit switch in uropathogenic Escherichia coli: quantitative analysis via automated model abstraction.

Authors: Hiroyuki Kuwahara; Chris J Myers; Michael S Samoilov
Journal: PLoS Comput Biol Date: 2010-03-26 Impact factor: 4.475

Fast, cheap and somewhat in control.

1. Intrinsic and extrinsic contributions to stochasticity in gene expression.

2. Control of stochasticity in eukaryotic gene expression.

Review 3. Reconstruction of genetic circuits.

4. Stochastic amplification and signaling in enzymatic futile cycles through noise-induced bistability with oscillations.

5. Phenotypic diversity, population growth, and information in fluctuating environments.

Review 6. Expanding the genetic code.

7. Stochastic protein expression in individual cells at the single molecule level.

8. Single-nutrient microbial competition: qualitative agreement between experimental and theoretically forecast outcomes.

9. Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise.

10. Spatiotemporal control of gene expression with pulse-generating networks.

Review 1. Biology by design: reduction and synthesis of cellular components and behaviour.

Review 2. Harnessing nature's toolbox: regulatory elements for synthetic biology.

3. A Biohybrid Device for the Systemic Control of Acute Inflammation.

4. Calculating life? A sociological perspective on systems biology.

5. A synthetic genetic edge detection program.

6. Mathematical modeling and synthetic biology.

7. Fine-tuning gene networks using simple sequence repeats.

8. Designing de novo: interdisciplinary debates in synthetic biology.

Review 9. Engineering reduced evolutionary potential for synthetic biology.

10. Temperature control of fimbriation circuit switch in uropathogenic Escherichia coli: quantitative analysis via automated model abstraction.