OBJECTIVES: We sought to implement and evaluate a high-performance, extended field of view protocol for time-resolved contrast-enhanced magnetic resonance imaging (CEMRA) of the carotid circulation by using a dedicated neurovascular (NV) array coil. MATERIALS AND METHODS: A total of 16 adult volunteers and 20 clinical patients with suspected cerebrovascular disease (15 male, 21 female, 25-82 years of age) were scanned with a fast 3D MRA sequence (TR/TE: 2.16/1 milliseconds, sampling BW: 1090 Hz/pixel), with echo-sharing and parallel acquisition. All studies were performed on a 3.0 T MR system using an 8-channel neurovascular array coil. After injection of 6 mL of gadodiamide at 3 mL/s, a coronal 3D data set with in-plane resolution of 1 x 1.3 was implemented for 10 consecutive measurements each 1.8 seconds apart. The subjects subsequently underwent high spatial-resolution (in-plane: 0.8 x 0.9) CEMRA for comparative analysis. The quality of segmental arterial anatomy and the presence and degree of the arterial stenosis were evaluated by 2 neuroradiologists. The interobserver variability was tested by kappa statistics and comparative analysis between the TR-CEMRA and high spatial-resolution CEMRA was evaluated by mean of the Spearman rank correlation coefficient. RESULTS: Craniocervical arteries were visualized with good image quality and definition in the diagnostic range. Occlusive disease was detected in 42 (reader A) and 44 (reader B) arterial segments with excellent interobserver agreement (kappa =0.89; 95% confidence interval 0.82-0.96). There was a significant correlation between the TR-CEMRA and high spatial-resolution CEMRA (Rs = 0.91 and 0.93, for readers A and B, respectively) for the degree of stenosis. Three aneurysms, 3 AVMs, 1 AV-fistula, and 2 subclavian steals were detected by both observers and were confirmed by correlative imaging. CONCLUSION: Time-resolved CEMRA at 3.0 T is reliable and versatile, providing 3-dimensional time-resolved data sets with high spatial (in plane: 1.3 x 1 mm2) and temporal (1.8 seconds) resolution over a large field of view. The higher signal-to-noise ratio gain at 3.0 T can be used effectively to improve performance of fast imaging and to support aggressive parallel acquisition protocols, as in the present study. Further clinical studies are required to establish the range of applications and the accuracy of the technique.
OBJECTIVES: We sought to implement and evaluate a high-performance, extended field of view protocol for time-resolved contrast-enhanced magnetic resonance imaging (CEMRA) of the carotid circulation by using a dedicated neurovascular (NV) array coil. MATERIALS AND METHODS: A total of 16 adult volunteers and 20 clinical patients with suspected cerebrovascular disease (15 male, 21 female, 25-82 years of age) were scanned with a fast 3D MRA sequence (TR/TE: 2.16/1 milliseconds, sampling BW: 1090 Hz/pixel), with echo-sharing and parallel acquisition. All studies were performed on a 3.0 T MR system using an 8-channel neurovascular array coil. After injection of 6 mL of gadodiamide at 3 mL/s, a coronal 3D data set with in-plane resolution of 1 x 1.3 was implemented for 10 consecutive measurements each 1.8 seconds apart. The subjects subsequently underwent high spatial-resolution (in-plane: 0.8 x 0.9) CEMRA for comparative analysis. The quality of segmental arterial anatomy and the presence and degree of the arterial stenosis were evaluated by 2 neuroradiologists. The interobserver variability was tested by kappa statistics and comparative analysis between the TR-CEMRA and high spatial-resolution CEMRA was evaluated by mean of the Spearman rank correlation coefficient. RESULTS: Craniocervical arteries were visualized with good image quality and definition in the diagnostic range. Occlusive disease was detected in 42 (reader A) and 44 (reader B) arterial segments with excellent interobserver agreement (kappa =0.89; 95% confidence interval 0.82-0.96). There was a significant correlation between the TR-CEMRA and high spatial-resolution CEMRA (Rs = 0.91 and 0.93, for readers A and B, respectively) for the degree of stenosis. Three aneurysms, 3 AVMs, 1 AV-fistula, and 2 subclavian steals were detected by both observers and were confirmed by correlative imaging. CONCLUSION: Time-resolved CEMRA at 3.0 T is reliable and versatile, providing 3-dimensional time-resolved data sets with high spatial (in plane: 1.3 x 1 mm2) and temporal (1.8 seconds) resolution over a large field of view. The higher signal-to-noise ratio gain at 3.0 T can be used effectively to improve performance of fast imaging and to support aggressive parallel acquisition protocols, as in the present study. Further clinical studies are required to establish the range of applications and the accuracy of the technique.
Authors: H Raoult; J-C Ferré; X Morandi; B Carsin-Nicol; M Carsin; M Cuggia; M Law; J-Y Gauvrit Journal: AJNR Am J Neuroradiol Date: 2010-05-06 Impact factor: 3.825
Authors: Alex Frydrychowicz; Thorsten A Bley; Jan T Winterer; Andreas Harloff; Mathias Langer; Jürgen Hennig; Michael Markl Journal: MAGMA Date: 2006-08-26 Impact factor: 2.310
Authors: R P Lim; M Shapiro; E Y Wang; M Law; J S Babb; L E Rueff; J S Jacob; S Kim; R H Carson; T P Mulholland; G Laub; E M Hecht Journal: AJNR Am J Neuroradiol Date: 2008-09-03 Impact factor: 3.825
Authors: Y Wu; N Kim; F R Korosec; A Turk; H A Rowley; O Wieben; C A Mistretta; P A Turski Journal: AJNR Am J Neuroradiol Date: 2007-10-10 Impact factor: 3.825
Authors: Stephen J Riederer; Clifton R Haider; Eric A Borisch; Paul T Weavers; Phillip M Young Journal: J Magn Reson Imaging Date: 2015-06-01 Impact factor: 4.813
Authors: Hee Kwon Song; Lirong Yan; Robert X Smith; Yiqun Xue; Stanislas Rapacchi; Subashini Srinivasan; Daniel B Ennis; Peng Hu; Nader Pouratian; Danny J J Wang Journal: Magn Reson Med Date: 2013-12-12 Impact factor: 4.668
Authors: Ulrike I Attenberger; Henrik J Michaely; Bernd J Wintersperger; Steven P Sourbron; Klaus-Peter Lodemann; Maximilian F Reiser; Stefan O Schoenberg Journal: Eur Radiol Date: 2008-02-16 Impact factor: 5.315