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Literature DB >> 15382508

Screening study for potential lead compounds for natural product-based fungicides: I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea.

Mourad Daoubi¹, Rosa Durán-Patrón, Mohamed Hmamouchi, Rosario Hernández-Galán, Ahmed Benharref, Isidro G Collado.

Abstract

An efficient, one-pot synthesis of angular and linear dihydropyranocoumarins, along with C-6 and C-8 prenylated coumarins is reported. These compounds, together with single- and furanocoumarins, were tested for their potential antifungal activity against the phytopathogen Botrytis cinerea Pers ex Fr. The results show that furanocoumarins may be able to control the fungus B cinerea.

Entities: Chemical Species

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Year: 2004 PMID： 15382508 DOI： 10.1002/ps.891

Source DB: PubMed Journal: Pest Manag Sci ISSN： 1526-498X Impact factor: 4.845

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Cited

25 in total

1. Forest soil metagenome gene cluster involved in antifungal activity expression in Escherichia coli.

Authors: Eu Jin Chung; He Kyoung Lim; Jin-Cheol Kim; Gyung Ja Choi; Eun Jin Park; Myung Hwan Lee; Young Ryun Chung; Seon-Woo Lee
Journal: Appl Environ Microbiol Date: 2007-12-07 Impact factor: 4.792

2. (1S,3R,8R)-2,2-Di-chloro-3,7,7,10-tetra-methyl-tri-cyclo-[6.4.0.0(1,3)]dodec-9-en-11-one.

Authors: Naja Ourhriss; Ahmed Benharref; Abdelouahd Oukhrib; Jean-Claude Daran; Moha Berraho
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2013-05-04

3. (1S,3R,8R)-2,2-Dibromo-3,7,7,10-tetra-methyl-tricyclo-[6.4.0.0(1,3)]dodec-9-ene.

Authors: Ahmed Benharref; Lahcen El Ammari; Essêdiya Lassaba; Najia Ourhriss; Moha Berraho
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2012-07-21

4. (1S,3R,8R,9R,10S)-2,2-Dibromo-3,7,7,10-tetra-methyl-9β,10β-ep-oxy-3,7,7,10-tetra-methyl-tricyclo-[6.4.0.0(1,3)]dodeca-ne.

Authors: Abdelouahd Oukhrib; Ahmed Benharref; Mohamed Saadi; Moha Berraho; Lahcen El Ammari
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2013-03-09

5. Forward Modeling of the Coumarin Antifungals; SPR/SAR Based Perspective.

Authors: Saeed Soltani; Shima Dianat; Soroush Sardari
Journal: Avicenna J Med Biotechnol Date: 2009-07

6. Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.

Authors: Rodrigo S A de Araújo; Felipe Q S Guerra; Edeltrudes de O Lima; Carlos A de Simone; Josean F Tavares; Luciana Scotti; Marcus T Scotti; Thiago M de Aquino; Ricardo O de Moura; Francisco J B Mendonça; José M Barbosa-Filho
Journal: Int J Mol Sci Date: 2013-01-10 Impact factor: 5.923

Screening study for potential lead compounds for natural product-based fungicides: I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea.

1. Forest soil metagenome gene cluster involved in antifungal activity expression in Escherichia coli.

2. (1S,3R,8R)-2,2-Di-chloro-3,7,7,10-tetra-methyl-tri-cyclo-[6.4.0.0(1,3)]dodec-9-en-11-one.

3. (1S,3R,8R)-2,2-Dibromo-3,7,7,10-tetra-methyl-tricyclo-[6.4.0.0(1,3)]dodec-9-ene.

4. (1S,3R,8R,9R,10S)-2,2-Dibromo-3,7,7,10-tetra-methyl-9β,10β-ep-oxy-3,7,7,10-tetra-methyl-tricyclo-[6.4.0.0(1,3)]dodeca-ne.

5. Forward Modeling of the Coumarin Antifungals; SPR/SAR Based Perspective.

6. Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.

7. (1S,3R,8R)-2,2-Dibromo-10-bromo-methyl-3,7,7-trimethyl-tricyclo-[6.4.0.0(1,3)]dodec-9-ene.

8. 2,2-Dichloro-3,7,7,11-tetra-methyl-10-aza-tetra-cyclo-[6.5.0.0(1,3).0(9,11)]trideca-ne.

9. (1S,3R,8R)-2,2-Dibromo-3,7,7,10-tetra-methyltricyclo-[6.4.0.0(1,3)]dodec-9-en-11-one.

10. (1S,3R,8R,9S,11R)-2,2,10,10-Tetra-chloro-3,7,7,11-tetra-methyl-tetra-cyclo-[6.5.0.0(1,3).0(9,11)]trideca-ne.