| Literature DB >> 15369356 |
Jérôme Collot1, Julieta Gradinaru, Nicolas Humbert, Myriem Skander, Andrea Zocchi, Thomas R Ward.
Abstract
Homogeneous and enzymatic catalysis offer complementary means to generate enantiomerically pure compounds. Incorporation of achiral biotinylated rhodium-diphosphine complexes into (strept)avidin yields artificial metalloenzymes for the hydrogenation of N-protected dehydroamino acids. A chemogenetic optimization procedure allows one to produce (R)-acetamidoalanine with 96% enantioselectivity. These hybrid catalysts display features reminiscent both of enzymatic and of homogeneous systems.Entities:
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Year: 2003 PMID： 15369356 DOI： 10.1021/ja035545i
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419