BACKGROUND: Previous estimates of the adenoma miss rate with optical colonoscopy (OC) are hindered by the use of OC as its own reference standard. OBJECTIVE: To evaluate the frequency and characteristics of colorectal neoplasms that are missed prospectively on OC by using virtual colonoscopy (VC) as a separate reference standard. DESIGN: Prospective, multicenter screening trial. SETTING: 3 medical centers. PARTICIPANTS: 1233 asymptomatic adults who underwent same-day VC and OC. MEASUREMENTS: Colorectal neoplasms (adenomatous polyps) missed at OC before VC results were unblinded. RESULTS: Fourteen (93.3%) of 15 nonrectal neoplasms were located on a fold; 10 (71.4%) of these were located on the backside of a fold. Five (83.3%) of 6 rectal lesions were located within 10 cm of the anal verge. LIMITATIONS: Estimation of the OC miss rate depended on polyp detection on both VC and second-look OC and therefore underestimates the true OC miss rate, particularly for smaller polyps. CONCLUSIONS: Most clinically significant adenomas missed prospectively on OC are located behind a fold or near the anal verge. The 12% OC miss rate for large adenomas (>or=10 mm) when state-of-the-art 3-dimensional VC is used as a separate reference standard is increased from the previous 0% to 6% estimates derived by using OC as its own reference standard.
BACKGROUND: Previous estimates of the adenoma miss rate with optical colonoscopy (OC) are hindered by the use of OC as its own reference standard. OBJECTIVE: To evaluate the frequency and characteristics of colorectal neoplasms that are missed prospectively on OC by using virtual colonoscopy (VC) as a separate reference standard. DESIGN: Prospective, multicenter screening trial. SETTING: 3 medical centers. PARTICIPANTS: 1233 asymptomatic adults who underwent same-day VC and OC. MEASUREMENTS: Colorectal neoplasms (adenomatous polyps) missed at OC before VC results were unblinded. RESULTS: Fourteen (93.3%) of 15 nonrectal neoplasms were located on a fold; 10 (71.4%) of these were located on the backside of a fold. Five (83.3%) of 6 rectal lesions were located within 10 cm of the anal verge. LIMITATIONS: Estimation of the OC miss rate depended on polyp detection on both VC and second-look OC and therefore underestimates the true OC miss rate, particularly for smaller polyps. CONCLUSIONS: Most clinically significant adenomas missed prospectively on OC are located behind a fold or near the anal verge. The 12% OC miss rate for large adenomas (>or=10 mm) when state-of-the-art 3-dimensional VC is used as a separate reference standard is increased from the previous 0% to 6% estimates derived by using OC as its own reference standard.
Authors: Amy B Knudsen; Iris Lansdorp-Vogelaar; Carolyn M Rutter; James E Savarino; Marjolein van Ballegooijen; Karen M Kuntz; Ann G Zauber Journal: J Natl Cancer Inst Date: 2010-07-27 Impact factor: 13.506
Authors: M F Kaminski; M Bretthauer; A G Zauber; E J Kuipers; H-O Adami; M van Ballegooijen; J Regula; M van Leerdam; T Stefansson; L Påhlman; E Dekker; M A Hernán; K Garborg; G Hoff Journal: Endoscopy Date: 2012-06-21 Impact factor: 10.093