Literature DB >> 14754441

The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

Heloisa Beraldo1, Dinorah Gambino.   

Abstract

The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.

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Year:  2004        PMID： 14754441     DOI： 10.2174/1389557043487484

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  73 in total

1.  Condensed-phase relative Gibbs free energy and E/Z descriptors for 2-acetylthiophene and 2-acetylthiophene-N1-phenyl thiosemicarbazones.

Authors:  Alice L R Sales; Josué M Silla; Jonas L Neto; Cleber P A Anconi
Journal:  J Mol Model       Date:  2021-03-04       Impact factor: 1.810

2.  Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein.

Authors:  Matthew D Hall; Kyle R Brimacombe; Matthew S Varonka; Kristen M Pluchino; Julie K Monda; Jiayang Li; Martin J Walsh; Matthew B Boxer; Timothy H Warren; Henry M Fales; Michael M Gottesman
Journal:  J Med Chem       Date:  2011-08-01       Impact factor: 7.446

3.  Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone: Synthesis, Crystal Structure, and Antiproliferative Activity.

Authors:  Joanna Wiecek; Dimitra Kovala-Demertzi; Zbigniew Ciunik; Joanna Wietrzyk; Maria Zervou; Mavroudis A Demertzis
Journal:  Bioinorg Chem Appl       Date:  2010-05-12       Impact factor: 7.778

4.  (E)-1-[4-(Dimethyl-amino)benzyl-idene]thio-semicarbazide.

Authors:  Yuying Sun; Shizhou Fu; Junhong Zhang; Xiao Wang; Daqi Wang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-08

5.  2-Benzoyl-pyridine semicarbazone.

Authors:  Daniel F de Lima; Anayive Pérez-Rebolledo; Javier Ellena; Heloisa Beraldo
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

6.  Di-μ-chlorido-bis-{[2-({[2-(2-pyrid-yl)eth-yl](2-pyridylmeth-yl)amino}meth-yl)phenol]zinc(II)} bis-(perchlorate) dihydrate.

Authors:  Sara E Coelho; Geovana G Terra; Adailton J Bortoluzzi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-01-30

7.  (E)-2-{(2-Hydroxy-naphthalen-1-yl)methyl-ene}hydrazinecarboxamide.

Authors:  Yousef M Hijji; Oyebola Oladeinde; Ray J Butcher; Jerry P Jasinski
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-04-25

8.  Benzaldehyde thio-semicarbazone.

Authors:  Lingqian Kong; Yan Qiao; Ji-Dong Zhang; Xiu-Ping Ju
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-11-22

9.  Pyridine-2-carbaldehyde thio-semi-carbazone.

Authors:  Li-Hua Song; Xiang Zhang; Kun Jiang; Sheng-Xiang Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-23

10.  Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells.

Authors:  Belkis Atasever; Bahri Ulküseven; Tülay Bal-Demirci; Serap Erdem-Kuruca; Zeynep Solakoğlu
Journal:  Invest New Drugs       Date:  2009-06-04       Impact factor: 3.850
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