Literature DB >> 14742217

Replacement of ParC alpha4 helix with that of GyrA increases the stability and cytotoxicity of topoisomerase IV-quinolone-DNA ternary complexes.

Emily S Pfeiffer1, Hiroshi Hiasa.   

Abstract

Replacement of the alpha4 helix of ParC with that of GyrA increased the stability of topoisomerase IV-quinolone-DNA ternary complexes. This mutant topoisomerase IV-mediated cell killing was more efficient than topoisomerase IV-mediated cell killing in Escherichia coli. Thus, the alpha4 helix plays critical roles in determining the stability and the cytotoxicity of ternary complexes.

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Year:  2004        PMID： 14742217      PMCID： PMC321561          DOI： 10.1128/AAC.48.2.608-611.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

1.  DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex.

Authors:  H Hiasa; D O Yousef; K J Marians
Journal:  J Biol Chem       Date:  1996-10-18       Impact factor: 5.157

Review 2.  DNA topoisomerases.

Authors:  J C Wang
Journal:  Annu Rev Biochem       Date:  1996       Impact factor: 23.643

3.  Two distinct modes of strand unlinking during theta-type DNA replication.

Authors:  H Hiasa; K J Marians
Journal:  J Biol Chem       Date:  1996-08-30       Impact factor: 5.157

4.  Gene splicing by overlap extension.

Authors:  R M Horton; S N Ho; J K Pullen; H D Hunt; Z Cai; L R Pease
Journal:  Methods Enzymol       Date:  1993       Impact factor: 1.600

5.  Structure and mechanism of DNA topoisomerase II.

Authors:  J M Berger; S J Gamblin; S C Harrison; J C Wang
Journal:  Nature       Date:  1996-01-18       Impact factor: 49.962

6.  Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance.

Authors:  X S Pan; L M Fisher
Journal:  J Bacteriol       Date:  1996-07       Impact factor: 3.490

7.  Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.

Authors:  L Ferrero; B Cameron; B Manse; D Lagneaux; J Crouzet; A Famechon; F Blanche
Journal:  Mol Microbiol       Date:  1994-08       Impact factor: 3.501

Review 8.  DNA gyrase: structure and function.

Authors:  R J Reece; A Maxwell
Journal:  Crit Rev Biochem Mol Biol       Date:  1991       Impact factor: 8.250

9.  Topoisomerase IV is a target of quinolones in Escherichia coli.

Authors:  A B Khodursky; E L Zechiedrich; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205

10.  A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors.

Authors:  Y Hsiung; S H Elsea; N Osheroff; J L Nitiss
Journal:  J Biol Chem       Date:  1995-09-01       Impact factor: 5.157
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  7 in total

1.  parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.

Authors:  Kendal M Galbraith; Amanda C Ng; Betsy J Eggers; Craig R Kuchel; Christian H Eggers; D Scott Samuels
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

2.  Role of the extended alpha4 domain of Staphylococcus aureus gyrase A protein in determining low sensitivity to quinolones.

Authors:  Jacob Strahilevitz; Ari Robicsek; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

Review 3.  Quinolone-mediated bacterial death.

Authors:  Karl Drlica; Muhammad Malik; Robert J Kerns; Xilin Zhao
Journal:  Antimicrob Agents Chemother       Date:  2007-08-27       Impact factor: 5.191

4.  The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone.

Authors:  Sarah R C Lentz; Pratik R Chheda; Lisa M Oppegard; Tyrell R Towle; Robert J Kerns; Hiroshi Hiasa
Journal:  Biochimie       Date:  2019-02-11       Impact factor: 4.079

5.  In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.

Authors:  Lisa M Oppegard; Bree L Hamann; Kathryn R Streck; Keith C Ellis; Hans-Peter Fiedler; Arkady B Khodursky; Hiroshi Hiasa
Journal:  Antimicrob Agents Chemother       Date:  2009-03-09       Impact factor: 5.191

6.  Molecular aspect on the interaction of zinc-ofloxacin complex with deoxyribonucleic acid, proposed model for binding and cytotoxicity evaluation.

Authors:  F Ahmadi; N Ebrahimi-Dishabi; K Mansouri; F Salimi
Journal:  Res Pharm Sci       Date:  2014 Sep-Oct

Review 7.  Quinolones: action and resistance updated.

Authors:  Karl Drlica; Hiroshi Hiasa; Robert Kerns; Muhammad Malik; Arkady Mustaev; Xilin Zhao
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295
  7 in total

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