Literature DB >> 1657531

DNA gyrase: structure and function.

R J Reece1, A Maxwell.   

Abstract

DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA. The mechanism by which gyrase is able to influence the topological state of DNA molecules is of inherent interest from an enzymological standpoint. In addition, much attention has been focused on DNA gyrase as the intracellular target of a number of antibacterial agents as a paradigm for other DNA topoisomerases. In this review we summarize the current knowledge concerning DNA gyrase by addressing a wide range of aspects of the study of this enzyme.

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Year:  1991        PMID： 1657531     DOI： 10.3109/10409239109114072

Source DB:  PubMed          Journal:  Crit Rev Biochem Mol Biol        ISSN： 1040-9238            Impact factor:   8.250


  174 in total

1.  A model for the mechanism of strand passage by DNA gyrase.

Authors:  S C Kampranis; A D Bates; A Maxwell
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

2.  Backbone resonance assignment of the N-terminal 24 kDa fragment of the gyrase B subunit from S. aureus complexed with novobiocin.

Authors:  W Klaus; A Ross; B Gsell; H Senn
Journal:  J Biomol NMR       Date:  2000-04       Impact factor: 2.835

3.  Ordered intracellular RecA-DNA assemblies: a potential site of in vivo RecA-mediated activities.

Authors:  S Levin-Zaidman; D Frenkiel-Krispin; E Shimoni; I Sabanay; S G Wolf; A Minsky
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

4.  Construction and characterization of mutations at codon 751 of the Escherichia coli gyrB gene that confer resistance to the antimicrobial peptide microcin B17 and alter the activity of DNA gyrase.

Authors:  F J del Castillo; I del Castillo; F Moreno
Journal:  J Bacteriol       Date:  2001-03       Impact factor: 3.490

5.  GyrI: a counter-defensive strategy against proteinaceous inhibitors of DNA gyrase.

Authors:  Monalisa Chatterji; Valakunja Nagaraja
Journal:  EMBO Rep       Date:  2002-02-15       Impact factor: 8.807

6.  In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites.

Authors:  D B Zamble; D A Miller; J G Heddle; A Maxwell; C T Walsh; F Hollfelder
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-26       Impact factor: 11.205

7.  Impact of gyrA and parC mutations on quinolone resistance, doubling time, and supercoiling degree of Escherichia coli.

Authors:  S Bagel; V Hüllen; B Wiedemann; P Heisig
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

8.  Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug-topoisomerase complexes.

Authors:  George Hong; Kenneth N Kreuzer
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-18       Impact factor: 11.205

9.  Identification of 5,6-dihydroimidazo[2,1-b]thiazoles as a new class of antimicrobial agents.

Authors:  Yangmei Li; Nina Bionda; Renee Fleeman; Hongjie Wang; Akihiko Ozawa; Richard A Houghten; Lindsey Shaw
Journal:  Bioorg Med Chem       Date:  2016-09-12       Impact factor: 3.641

10.  Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.

Authors:  Lisa M Oppegard; Andrei V Ougolkov; Doris N Luchini; Renee A Schoon; John R Goodell; Harneet Kaur; Daniel D Billadeau; David M Ferguson; Hiroshi Hiasa
Journal:  Eur J Pharmacol       Date:  2008-12-03       Impact factor: 4.432
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