Literature DB >> 8538787

Structure and mechanism of DNA topoisomerase II.

J M Berger1, S J Gamblin, S C Harrison, J C Wang.   

Abstract

The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.

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Year:  1996        PMID： 8538787     DOI： 10.1038/379225a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  192 in total

1.  Cloning and characterization of a cDNA encoding topoisomerase II in pea and analysis of its expression in relation to cell proliferation.

Authors:  M K Reddy; S Nair; K K Tewari; Y Mudgil; B S Yadav; S K Sopory
Journal:  Plant Mol Biol       Date:  1999-09       Impact factor: 4.076

2.  A model for the mechanism of strand passage by DNA gyrase.

Authors:  S C Kampranis; A D Bates; A Maxwell
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

3.  Crystal structure of NaeI-an evolutionary bridge between DNA endonuclease and topoisomerase.

Authors:  Q Huai; J D Colandene; Y Chen; F Luo; Y Zhao; M D Topal; H Ke
Journal:  EMBO J       Date:  2000-06-15       Impact factor: 11.598

4.  Functional elements within the dynein microtubule-binding domain.

Authors:  M P Koonce; I Tikhonenko
Journal:  Mol Biol Cell       Date:  2000-02       Impact factor: 4.138

5.  Construction and characterization of mutations at codon 751 of the Escherichia coli gyrB gene that confer resistance to the antimicrobial peptide microcin B17 and alter the activity of DNA gyrase.

Authors:  F J del Castillo; I del Castillo; F Moreno
Journal:  J Bacteriol       Date:  2001-03       Impact factor: 3.490

6.  New mutation in parE in a pneumococcal in vitro mutant resistant to fluoroquinolones.

Authors:  C Janoir; E Varon; M D Kitzis; L Gutmann
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

7.  Mutations in the C-terminal domain of topoisomerase II affect meiotic function and interaction with the casein kinase 2 beta subunit.

Authors:  D Leroy; G C Alghisi; E Roberts; O Filhol-Cochet; S M Gasser
Journal:  Mol Cell Biochem       Date:  1999-01       Impact factor: 3.396

8.  Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.

Authors:  J C Young; F U Hartl
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

9.  Two tricks in one bundle: helix-turn-helix gains enzymatic activity.

Authors:  N V Grishin
Journal:  Nucleic Acids Res       Date:  2000-06-01       Impact factor: 16.971

10.  Differential responses of Bcl-2 family genes to etoposide in chronic myeloid leukemia K562 cells.

Authors:  S Fukumi; J Horiguchi-Yamada; S Nakada; M Nagai; T Ohno; H Yamada
Journal:  Mol Cell Biochem       Date:  2000-03       Impact factor: 3.396
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