Literature DB >> 8702938

Two distinct modes of strand unlinking during theta-type DNA replication.

H Hiasa1, K J Marians.   

Abstract

DNA gyrase and topoisomerase IV (Topo IV) are type II bacterial DNA topoisomerases that show a high degree of similarity to each other yet appear to have different functions during DNA replication. We show here that the torsional stress generated during theta-type DNA replication in vitro can take the form of either positive supercoils ahead of the replication fork or catenane-like right-handed windings (precatenanes) of the two partially replicated duplexes behind the fork. Gyrase prefers to act on the former, whereas Topo IV prefers the latter. Removal of either form of positive winding can support nascent chain elongation, but only precatenane removal can support the final stages of DNA replication: processing of the late intermediate and daughter chromosome decatenation.

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Year:  1996        PMID： 8702938     DOI： 10.1074/jbc.271.35.21529

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  35 in total

1.  Topoisomerase II can unlink replicating DNA by precatenane removal.

Authors:  I Lucas; T Germe; M Chevrier-Miller; O Hyrien
Journal:  EMBO J       Date:  2001-11-15       Impact factor: 11.598

Review 2.  Topological challenges to DNA replication: conformations at the fork.

Authors:  L Postow; N J Crisona; B J Peter; C D Hardy; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

3.  Preferential relaxation of positively supercoiled DNA by E. coli topoisomerase IV in single-molecule and ensemble measurements.

Authors:  N J Crisona; T R Strick; D Bensimon; V Croquette; N R Cozzarelli
Journal:  Genes Dev       Date:  2000-11-15       Impact factor: 11.361

4.  Replacement of ParC alpha4 helix with that of GyrA increases the stability and cytotoxicity of topoisomerase IV-quinolone-DNA ternary complexes.

Authors:  Emily S Pfeiffer; Hiroshi Hiasa
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191

5.  Single-molecule study of DNA unlinking by eukaryotic and prokaryotic type-II topoisomerases.

Authors:  G Charvin; D Bensimon; V Croquette
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-05       Impact factor: 11.205

6.  Reconstitution of recombination-dependent DNA synthesis in herpes simplex virus 1.

Authors:  Amitabh V Nimonkar; Paul E Boehmer
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-19       Impact factor: 11.205

7.  Topoisomerase IV bends and overtwists DNA upon binding.

Authors:  G Charvin; T R Strick; D Bensimon; V Croquette
Journal:  Biophys J       Date:  2005-04-29       Impact factor: 4.033

8.  Mechanisms of chiral discrimination by topoisomerase IV.

Authors:  K C Neuman; G Charvin; D Bensimon; V Croquette
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-09       Impact factor: 11.205

9.  Structural basis for the MukB-topoisomerase IV interaction and its functional implications in vivo.

Authors:  Seychelle M Vos; Nichole K Stewart; Martha G Oakley; James M Berger
Journal:  EMBO J       Date:  2013-10-04       Impact factor: 11.598

10.  Overexpression, purification, crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of the GyrA subunit of DNA gyrase from Staphylococcus aureus strain Mu50.

Authors:  Tae-O Kim; Ha Yun Jung; Soo Young Lee; Dong-Won Im; Whanchul Shin; Yong-Seok Heo
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-01-27
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