Literature DB >> 16189120

parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.

Kendal M Galbraith1, Amanda C Ng, Betsy J Eggers, Craig R Kuchel, Christian H Eggers, D Scott Samuels.   

Abstract

We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

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Year:  2005        PMID： 16189120      PMCID： PMC1251557          DOI： 10.1128/AAC.49.10.4354-4357.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  38 in total

1.  Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756.

Authors:  J C Fung-Tomc; B Minassian; B Kolek; E Huczko; L Aleksunes; T Stickle; T Washo; E Gradelski; L Valera; D P Bonner
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

2.  Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.

Authors:  A Sugino; C L Peebles; K N Kreuzer; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

3.  A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex.

Authors:  C J Willmott; A Maxwell
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

4.  Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

Authors:  H Yoshida; M Bogaki; M Nakamura; S Nakamura
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

5.  Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones.

Authors:  M E Cullen; A W Wyke; R Kuroda; L M Fisher
Journal:  Antimicrob Agents Chemother       Date:  1989-06       Impact factor: 5.191

Review 6.  DNA gyrase: structure and function.

Authors:  R J Reece; A Maxwell
Journal:  Crit Rev Biochem Mol Biol       Date:  1991       Impact factor: 8.250

7.  In vitro antimicrobial susceptibility testing of Borrelia burgdorferi: a microdilution MIC method and time-kill studies.

Authors:  L L Dever; J H Jorgensen; A G Barbour
Journal:  J Clin Microbiol       Date:  1992-10       Impact factor: 5.948

8.  Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; T Itoh; J I Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

9.  Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends.

Authors:  A G Barbour; C F Garon
Journal:  Science       Date:  1987-07-24       Impact factor: 47.728

10.  Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli.

Authors:  E L Zechiedrich; A B Khodursky; S Bachellier; R Schneider; D Chen; D M Lilley; N R Cozzarelli
Journal:  J Biol Chem       Date:  2000-03-17       Impact factor: 5.157
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  6 in total

1.  Mutations conferring aminoglycoside and spectinomycin resistance in Borrelia burgdorferi.

Authors:  Daniel Criswell; Virginia L Tobiason; J Stephen Lodmell; D Scott Samuels
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

Review 2.  Genetic Manipulation of Borrelia Spp.

Authors:  Dan Drecktrah; D Scott Samuels
Journal:  Curr Top Microbiol Immunol       Date:  2018       Impact factor: 4.291

Review 3.  Genetics of Borrelia burgdorferi.

Authors:  Dustin Brisson; Dan Drecktrah; Christian H Eggers; D Scott Samuels
Journal:  Annu Rev Genet       Date:  2012-09-04       Impact factor: 16.830

Review 4.  Antimicrobial susceptibility of Borrelia burgdorferi sensu lato: what we know, what we don't know, and what we need to know.

Authors:  Klaus-Peter Hunfeld; Volker Brade
Journal:  Wien Klin Wochenschr       Date:  2006-11       Impact factor: 1.704

5.  Borrelia burgdorferi resistance to a major skin antimicrobial peptide is independent of outer surface lipoprotein content.

Authors:  Amit Sarkar; Kit Tilly; Philip Stewart; Aaron Bestor; James M Battisti; Patricia A Rosa
Journal:  Antimicrob Agents Chemother       Date:  2009-08-03       Impact factor: 5.191

6.  RNase III Processing of rRNA in the Lyme Disease Spirochete Borrelia burgdorferi.

Authors:  Melissa L Anacker; Dan Drecktrah; Richard D LeCoultre; Meghan Lybecker; D Scott Samuels
Journal:  J Bacteriol       Date:  2018-06-11       Impact factor: 3.490
  6 in total

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