Literature DB >> 1367432

Measuring and increasing protein stability.

C N Pace1.   

Abstract

Recently, it has become possible to construct proteins to order and this has promoted interest in learning how to increase their stability. This article describes recent developments in the methods used to measure the conformational stability of globular proteins, and discusses the approaches being used to increase their stability.

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Year:  1990        PMID： 1367432     DOI： 10.1016/0167-7799(90)90146-o

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  92 in total

1.  Increasing protein stability by altering long-range coulombic interactions.

Authors:  G R Grimsley; K L Shaw; L R Fee; R W Alston; B M Huyghues-Despointes; R L Thurlkill; J M Scholtz; C N Pace
Journal:  Protein Sci       Date:  1999-09       Impact factor: 6.725

2.  Active-site sulfhydryl chemistry plays a major role in the misfolding of urea-denatured rhodanese.

Authors:  M Panda; P M Horowitz
Journal:  J Protein Chem       Date:  2000-07

3.  Pressure versus temperature unfolding of ribonuclease A: an FTIR spectroscopic characterization of 10 variants at the carboxy-terminal site.

Authors:  J Torrent; P Rubens; M Ribó; K Heremans; M Vilanova
Journal:  Protein Sci       Date:  2001-04       Impact factor: 6.725

4.  Heat capacity change for ribonuclease A folding.

Authors:  C N Pace; G R Grimsley; S T Thomas; G I Makhatadze
Journal:  Protein Sci       Date:  1999-07       Impact factor: 6.725

5.  Early melting of supercoiled DNA topoisomers observed by TGGE.

Authors:  V Víglaský; M Antalík; J Adamcík; D Podhradský
Journal:  Nucleic Acids Res       Date:  2000-06-01       Impact factor: 16.971

6.  Removal of surface charge-charge interactions from ubiquitin leaves the protein folded and very stable.

Authors:  Vakhtang V Loladze; George I Makhatadze
Journal:  Protein Sci       Date:  2002-01       Impact factor: 6.725

7.  Single-domain antibody fragments with high conformational stability.

Authors:  Mireille Dumoulin; Katja Conrath; Annemie Van Meirhaeghe; Filip Meersman; Karel Heremans; Leon G J Frenken; Serge Muyldermans; Lode Wyns; Andre Matagne
Journal:  Protein Sci       Date:  2002-03       Impact factor: 6.725

8.  Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.

Authors:  Eva Y Chi; Sampathkumar Krishnan; Brent S Kendrick; Byeong S Chang; John F Carpenter; Theodore W Randolph
Journal:  Protein Sci       Date:  2003-05       Impact factor: 6.725

9.  Thermal stability of bovine-brain myelin membrane.

Authors:  J Ruiz-Sanz; J Ruiz-Cabello; O Lopez-Mayorga; M Cortijo; P L Mateo
Journal:  Eur Biophys J       Date:  1992       Impact factor: 1.733

10.  Increasing protein conformational stability by optimizing beta-turn sequence.

Authors:  Saul R Trevino; Stephanie Schaefer; J Martin Scholtz; C Nick Pace
Journal:  J Mol Biol       Date:  2007-08-09       Impact factor: 5.469
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