Literature DB >> 12889960

Inactivation of acetyl-CoA synthase/carbon monoxide dehydrogenase by copper.

Matthew R Bramlett1, Xiangshi Tan, Paul A Lindahl.   

Abstract

Two recent crystal structures of acetyl-CoA synthase (ACS) from Moorella thermoacetica exhibited different metal contents and geometries at their active site, called the A-cluster. This led to the proposal of two catalytic mechanisms, one Ni-based, the other Cu-based. ACS was studied with respect to synthase activity, methyl group transfer activity, metal content, and EPR spectroscopy. Our results indicate that Cu is not required for catalysis and that it inactivates ACS by binding to the proximal site of the A-cluster. With Cu in this site, the A-cluster cannot accept a methyl group from the corrinoid-iron-sulfur protein, nor can it exhibit the NiFeC EPR signal after treatment with CO.

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Year:  2003        PMID： 12889960     DOI： 10.1021/ja0352855

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  19 in total

Review 1.  Spectroscopic and computational insights into the geometric and electronic properties of the A-cluster of acetyl-coenzyme A synthase.

Authors:  Thomas C Brunold
Journal:  J Biol Inorg Chem       Date:  2004-06-24       Impact factor: 3.358

2.  Bisamidate and mixed amine/amidate NiN2S2 complexes as models for nickel-containing acetyl coenzyme A synthase and superoxide dismutase: an experimental and computational study.

Authors:  Vaidyanathan Mathrubootham; Jason Thomas; Richard Staples; John McCraken; Jason Shearer; Eric L Hegg
Journal:  Inorg Chem       Date:  2010-06-21       Impact factor: 5.165

3.  Nickel-dependent oligomerization of the alpha subunit of acetyl-coenzyme a synthase/carbon monoxide dehydrogenase.

Authors:  Xiangshi Tan; Ioannis Kagiampakis; Ivan V Surovtsev; Borries Demeler; Paul A Lindahl
Journal:  Biochemistry       Date:  2007-09-22       Impact factor: 3.162

Review 4.  Frontiers, opportunities, and challenges in biochemical and chemical catalysis of CO2 fixation.

Authors:  Aaron M Appel; John E Bercaw; Andrew B Bocarsly; Holger Dobbek; Daniel L DuBois; Michel Dupuis; James G Ferry; Etsuko Fujita; Russ Hille; Paul J A Kenis; Cheryl A Kerfeld; Robert H Morris; Charles H F Peden; Archie R Portis; Stephen W Ragsdale; Thomas B Rauchfuss; Joost N H Reek; Lance C Seefeldt; Rudolf K Thauer; Grover L Waldrop
Journal:  Chem Rev       Date:  2013-06-14       Impact factor: 60.622

Review 5.  Metal centers in the anaerobic microbial metabolism of CO and CO2.

Authors:  Güneş Bender; Elizabeth Pierce; Jeffrey A Hill; Joseph E Darty; Stephen W Ragsdale
Journal:  Metallomics       Date:  2011-06-06       Impact factor: 4.526

6.  Synthesis of MFe3S4 clusters containing a planar M(II) site (M = Ni, Pd, Pt), a structural element in the C-cluster of carbon monoxide dehydrogenase.

Authors:  Rashmishree Panda; Curtis P Berlinguette; Yugen Zhang; Richard H Holm
Journal:  J Am Chem Soc       Date:  2005-08-10       Impact factor: 15.419

7.  Modeling carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS): a trinuclear nickel complex employing deprotonated amides and bridging thiolates.

Authors:  Øyvind Hatlevik; Mary C Blanksma; Vaidyanathan Mathrubootham; Atta M Arif; Eric L Hegg
Journal:  J Biol Inorg Chem       Date:  2004-01-21       Impact factor: 3.358

Review 8.  The metalloclusters of carbon monoxide dehydrogenase/acetyl-CoA synthase: a story in pictures.

Authors:  Catherine L Drennan; Tzanko I Doukov; Stephen W Ragsdale
Journal:  J Biol Inorg Chem       Date:  2004-06-18       Impact factor: 3.358

Review 9.  Synthetic chemistry and chemical precedents for understanding the structure and function of acetyl coenzyme A synthase.

Authors:  Charles G Riordan
Journal:  J Biol Inorg Chem       Date:  2004-06-24       Impact factor: 3.358

Review 10.  Acetyl-coenzyme A synthase: the case for a Ni(p)(0)-based mechanism of catalysis.

Authors:  Paul A Lindahl
Journal:  J Biol Inorg Chem       Date:  2004-06-25       Impact factor: 3.358
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