Literature DB >> 12570844

Inhibitors of lysine biosynthesis as antibacterial agents.

Craig A Hutton1, Timothy J Southwood, Jennifer J Turner.   

Abstract

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.

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Year:  2003        PMID： 12570844     DOI： 10.2174/1389557033405359

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  36 in total

1.  Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapC (Rv0858c) from Mycobacterium tuberculosis.

Authors:  Simone Weyand; Georgia Kefala; Manfred S Weiss
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-07-25

2.  Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapA (Rv2753c) from Mycobacterium tuberculosis.

Authors:  Georgia Kefala; Manfred S Weiss
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-10-20

3.  X-ray structure of Paramecium bursaria Chlorella virus arginine decarboxylase: insight into the structural basis for substrate specificity.

Authors:  Rahul Shah; Radha Akella; Elizabeth J Goldsmith; Margaret A Phillips
Journal:  Biochemistry       Date:  2007-02-17       Impact factor: 3.162

4.  A loop loop interaction and a K-turn motif located in the lysine aptamer domain are important for the riboswitch gene regulation control.

Authors:  Simon Blouin; Daniel A Lafontaine
Journal:  RNA       Date:  2007-06-21       Impact factor: 4.942

5.  Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of LysA (Rv1293) from Mycobacterium tuberculosis.

Authors:  Georgia Kefala; L Jeanne Perry; Manfred S Weiss
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2005-07-30

6.  Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapB (Rv2773c) from Mycobacterium tuberculosis.

Authors:  Georgia Kefala; Robert Janowski; Santosh Panjikar; Christoph Mueller-Dieckmann; Manfred S Weiss
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2005-06-30

7.  The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans.

Authors:  Eunsoo Do; Minji Park; Guanggan Hu; Mélissa Caza; James W Kronstad; Won Hee Jung
Journal:  Biochem Biophys Res Commun       Date:  2016-06-25       Impact factor: 3.575

8.  Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

Authors:  Sudhir Dommaraju; Michael A Gorman; Con Dogovski; F Grant Pearce; Juliet A Gerrard; Renwick C J Dobson; Michael W Parker; Matthew A Perugini
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-12-25

9.  Dimerization of bacterial diaminopimelate epimerase is essential for catalysis.

Authors:  Lilian Hor; Renwick C J Dobson; Matthew T Downton; John Wagner; Craig A Hutton; Matthew A Perugini
Journal:  J Biol Chem       Date:  2013-02-19       Impact factor: 5.157

10.  Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli.

Authors:  Lilian Hor; Renwick C J Dobson; Con Dogovski; Craig A Hutton; Matthew A Perugini
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-12-25
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