| Literature DB >> 11850290 |
Mariagrazia Perilli1, Bernardetta Segatore, Maria Rosaria De Massis, Nicola Franceschini, Ciro Bianchi, Gian Maria Rossolini, Gianfranco Amicosante.
Abstract
A new natural TEM derivative, named TEM-87, was identified in a Proteus mirabilis isolate from an Italian hospital. Compared to TEM-1, TEM-87 contains the following mutations: E104K, R164C, and M182T. Kinetic analysis of TEM-87 revealed extended-spectrum activity against oxyimino cephalosporins (preferentially ceftazidime) and aztreonam. Expression of blaTEM-87 in Escherichia coli decreased the host susceptibility to these drugs.Entities:
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Year: 2002 PMID: 11850290 PMCID: PMC127476 DOI: 10.1128/AAC.46.3.925-928.2002
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191