Literature DB >> 29941651

TEM-184, a Novel TEM-Derived Extended-Spectrum β-Lactamase with Enhanced Activity against Aztreonam.

Alessandra Piccirilli1, Mariagrazia Perilli1, Gianfranco Amicosante1, Viola Conte2, Carlo Tascini3, Gian Maria Rossolini4,5, Tommaso Giani6.   

Abstract

TEM-184, a novel TEM-derived extended-spectrum β-lactamase (ESBL), was isolated from an Escherichia coli ST354 clinical strain. Compared to TEM-1, TEM-184 contains the mutations Q6K, E104K, I127V, R164S, and M182T. Kinetic analysis of this enzyme revealed extended-spectrum activity against aztreonam in particular. TEM-184 was also susceptible to inhibitors, including clavulanic acid, tazobactam, and avibactam.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  ESBL; avibactam; inhibitors

Mesh：

Substances：

Year:  2018        PMID： 29941651      PMCID： PMC6125571          DOI： 10.1128/AAC.00688-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates.

Authors:  Mariagrazia Perilli; Giuseppe Celenza; Francesca De Santis; Cristina Pellegrini; Chiara Forcella; Gian Maria Rossolini; Stefania Stefani; Gianfranco Amicosante
Journal:  Antimicrob Agents Chemother       Date:  2007-12-26       Impact factor: 5.191

2.  Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea.

Authors:  Kyungwon Lee; Jong Hwa Yum; Dongeun Yong; Seok Hoon Jeong; Gian Maria Rossolini; Jean-Denis Docquier; Yunsop Chong
Journal:  Antimicrob Agents Chemother       Date:  2011-09-12       Impact factor: 5.191

3.  A natural polymorphism in beta-lactamase is a global suppressor.

Authors:  W Huang; T Palzkill
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

4.  Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases.

Authors:  F De Meester; B Joris; G Reckinger; C Bellefroid-Bourguignon; J M Frère; S G Waley
Journal:  Biochem Pharmacol       Date:  1987-07-15       Impact factor: 5.858

5.  Emergence of Escherichia coli ST131 sub-clone H30 producing VIM-1 and KPC-3 carbapenemases, Italy.

Authors:  Marisa Accogli; Tommaso Giani; Monica Monaco; Maria Giufrè; Aurora García-Fernández; Viola Conte; Fortunato D'Ancona; Annalisa Pantosti; Gian Maria Rossolini; Marina Cerquetti
Journal:  J Antimicrob Chemother       Date:  2014-05-05       Impact factor: 5.790

Review 6.  Extended-spectrum beta-lactamases.

Authors:  A Philippon; R Labia; G Jacoby
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

7.  TEM beta-lactamase mutants hydrolysing third-generation cephalosporins. A kinetic and molecular modelling analysis.

Authors:  X Raquet; J Lamotte-Brasseur; E Fonzé; S Goussard; P Courvalin; J M Frère
Journal:  J Mol Biol       Date:  1994-12-16       Impact factor: 5.469

8.  TEM-80, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Enterobacter cloacae.

Authors:  Corinne Arpin; Roger Labia; Véronique Dubois; Patrick Noury; Muriel Souquet; Claudine Quentin
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

9.  Characterization of a new extended-spectrum beta-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey.

Authors:  Mariagrazia Perilli; Bernardetta Segatore; Maria Rosaria De Massis; Nicola Franceschini; Ciro Bianchi; Gian Maria Rossolini; Gianfranco Amicosante
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

10.  Multiply resistant Klebsiella pneumoniae strains from two Chicago hospitals: identification of the extended-spectrum TEM-12 and TEM-10 ceftazidime-hydrolyzing beta-lactamases in a single isolate.

Authors:  P A Bradford; C E Cherubin; V Idemyor; B A Rasmussen; K Bush
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191
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  1 in total

Review 1.  Extended-spectrum β-lactamases: an update on their characteristics, epidemiology and detection.

Authors:  Mariana Castanheira; Patricia J Simner; Patricia A Bradford
Journal:  JAC Antimicrob Resist       Date:  2021-07-16
  1 in total

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