Literature DB >> 15328132

Biochemical characterization of laboratory mutants of extended-spectrum beta-lactamase TEM-60.

Bibiana Caporale1, Nicola Franceschini, Mariagrazia Perilli, Bernardetta Segatore, Gian Maria Rossolini, Gianfranco Amicosante.   

Abstract

Three mutants of the extended-spectrum beta-lactamase TEM-60, the P51L, K104E, and S164R mutants, were constructed by site-directed mutagenesis. The kinetic parameters of the mutated enzymes and interactions of inhibitors were significantly different from those of TEM-60, revealing that the L51P mutation plays an important role in enzyme activity and stability in the TEM-60 background.

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Year:  2004        PMID： 15328132      PMCID： PMC514782          DOI： 10.1128/AAC.48.9.3579-3582.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

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Journal:  Clin Microbiol Rev       Date:  2001-10       Impact factor: 26.132

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Authors:  N Franceschini; M Perilli; B Segatore; D Setacci; G Amicosante; A Mazzariol; G Cornaglia
Journal:  Antimicrob Agents Chemother       Date:  1998-06       Impact factor: 5.191

4.  6-beta-Iodopenicillanate as a probe for the classification of beta-lactamases.

Authors:  F De Meester; J M Frère; S G Waley; S J Cartwright; R Virden; F Lindberg
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5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

Review 6.  Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.

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Journal:  Antimicrob Agents Chemother       Date:  1995-12       Impact factor: 5.191

7.  TEM beta-lactamase mutants hydrolysing third-generation cephalosporins. A kinetic and molecular modelling analysis.

Authors:  X Raquet; J Lamotte-Brasseur; E Fonzé; S Goussard; P Courvalin; J M Frère
Journal:  J Mol Biol       Date:  1994-12-16       Impact factor: 5.469

8.  Characterization of a new extended-spectrum beta-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey.

Authors:  Mariagrazia Perilli; Bernardetta Segatore; Maria Rosaria De Massis; Nicola Franceschini; Ciro Bianchi; Gian Maria Rossolini; Gianfranco Amicosante
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

Review 9.  Extended-spectrum beta-lactamases and other enzymes providing resistance to oxyimino-beta-lactams.

Authors:  G A Jacoby
Journal:  Infect Dis Clin North Am       Date:  1997-12       Impact factor: 5.982

10.  Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds.

Authors:  M Galleni; N Franceschini; B Quinting; L Fattorini; G Orefici; A Oratore; J M Frère; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191
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  3 in total

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Authors:  Chris Avery; Lonnie Baker; Donald J Jacobs
Journal:  Entropy (Basel)       Date:  2022-05-20       Impact factor: 2.738

2.  Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1.

Authors:  André Birgy; Mélanie Magnan; Claire Amaris Hobson; Matteo Figliuzzi; Karine Panigoni; Cyrielle Codde; Olivier Tenaillon; Hervé Jacquier
Journal:  Antibiotics (Basel)       Date:  2022-05-13

3.  Network models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectories.

Authors:  Violeta Beleva Guthrie; Jennifer Allen; Manel Camps; Rachel Karchin
Journal:  PLoS Comput Biol       Date:  2011-09-22       Impact factor: 4.475
  3 in total

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