Literature DB >> 11805306

Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution.

David A Bushnell1, Patrick Cramer, Roger D Kornberg.   

Abstract

The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11805306      PMCID： PMC122170          DOI： 10.1073/pnas.251664698

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution.

Authors:  G Zhang; E A Campbell; L Minakhin; C Richter; K Severinov; S A Darst
Journal:  Cell       Date:  1999-09-17       Impact factor: 41.582

Review 2.  Databases in protein crystallography.

Authors:  G J Kleywegt; T A Jones
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1998-11-01

Review 3.  Fifty years of amanitin.

Authors:  T Wieland; H Faulstich
Journal:  Experientia       Date:  1991-12-01

4.  Nascent RNA cleavage by arrested RNA polymerase II does not require upstream translocation of the elongation complex on DNA.

Authors:  W Gu; W Powell; J Mote; D Reines
Journal:  J Biol Chem       Date:  1993-12-05       Impact factor: 5.157

5.  An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.

Authors:  R M Esnouf
Journal:  J Mol Graph Model       Date:  1997-04       Impact factor: 2.518

6.  Clustered alpha-amanitin resistance mutations in mouse.

Authors:  M S Bartolomei; J L Corden
Journal:  Mol Gen Genet       Date:  1995-03-20

7.  Formation of a single phosphodiester bond by RNA polymerase B from calf thymus is not inhibited by alpha-amanitin.

Authors:  A C Vaisius; T Wieland
Journal:  Biochemistry       Date:  1982-06-22       Impact factor: 3.162

8.  Amanitin greatly reduces the rate of transcription by RNA polymerase II ternary complexes but fails to inhibit some transcript cleavage modes.

Authors:  M D Rudd; D S Luse
Journal:  J Biol Chem       Date:  1996-08-30       Impact factor: 5.157

9.  Mapping mutations in genes encoding the two large subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes.

Authors:  Y Chen; J Weeks; M A Mortin; A L Greenleaf
Journal:  Mol Cell Biol       Date:  1993-07       Impact factor: 4.272

10.  Unexpected similarity of the structures of the weakly toxic amanitin (S)-sulfoxide and the highly toxic (R)-sulfoxide and sulfone as revealed by proton nuclear magnetic resonance and X-ray analysis.

Authors:  T Wieland; C Götzendörfer; J Dabrowski; W N Lipscomb; G Shoham
Journal:  Biochemistry       Date:  1983-03-01       Impact factor: 3.162
View more
  98 in total

1.  RNA polymerase mutations that impair conversion to a termination-resistant complex by Q antiterminator proteins.

Authors:  Thomas J Santangelo; Rachel Anne Mooney; Robert Landick; Jeffrey W Roberts
Journal:  Genes Dev       Date:  2003-05-15       Impact factor: 11.361

Review 2.  Structure and mechanism of the RNA polymerase II transcription machinery.

Authors:  Steven Hahn
Journal:  Nat Struct Mol Biol       Date:  2004-05       Impact factor: 15.369

3.  The effect of alpha-amanitin on the Arabidopsis seed proteome highlights the distinct roles of stored and neosynthesized mRNAs during germination.

Authors:  Loïc Rajjou; Karine Gallardo; Isabelle Debeaujon; Joël Vandekerckhove; Claudette Job; Dominique Job
Journal:  Plant Physiol       Date:  2004-03-26       Impact factor: 8.340

4.  Transcription factor binding and induced transcription alter chromosomal c-myc replicator activity.

Authors:  M Ghosh; G Liu; G Randall; J Bevington; M Leffak
Journal:  Mol Cell Biol       Date:  2004-12       Impact factor: 4.272

5.  BRG1 helps RNA polymerase II to overcome a nucleosomal barrier during elongation, in vivo.

Authors:  Alicia Subtil-Rodríguez; José C Reyes
Journal:  EMBO Rep       Date:  2010-09-10       Impact factor: 8.807

6.  The conserved foot domain of RNA pol II associates with proteins involved in transcriptional initiation and/or early elongation.

Authors:  M Carmen García-López; Vicent Pelechano; M Carmen Mirón-García; Ana I Garrido-Godino; Alicia García; Olga Calvo; Michel Werner; José E Pérez-Ortín; Francisco Navarro
Journal:  Genetics       Date:  2011-09-27       Impact factor: 4.562

7.  Retinoids synergize with insulin to induce hepatic Gck expression.

Authors:  Guoxun Chen; Yan Zhang; Danhong Lu; Nan-Qian Li; A Catharine Ross
Journal:  Biochem J       Date:  2009-05-01       Impact factor: 3.857

8.  Circadian gene expression is resilient to large fluctuations in overall transcription rates.

Authors:  Charna Dibner; Daniel Sage; Michael Unser; Christoph Bauer; Thomas d'Eysmond; Felix Naef; Ueli Schibler
Journal:  EMBO J       Date:  2008-12-11       Impact factor: 11.598

Review 9.  Transcription termination by the eukaryotic RNA polymerase III.

Authors:  Aneeshkumar G Arimbasseri; Keshab Rijal; Richard J Maraia
Journal:  Biochim Biophys Acta       Date:  2012-10-23

Review 10.  Budding yeast for budding geneticists: a primer on the Saccharomyces cerevisiae model system.

Authors:  Andrea A Duina; Mary E Miller; Jill B Keeney
Journal:  Genetics       Date:  2014-05       Impact factor: 4.562
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.