Literature DB >> 1765129

Fifty years of amanitin.

T Wieland1, H Faulstich.   

Abstract

Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, alpha-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis.

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Year:  1991        PMID： 1765129     DOI： 10.1007/bf01918382

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  31 in total

1.  The crystal structure of the mushroom toxin beta-amanitin.

Authors:  E C Kostansek; W N Lipscomb; R R Yocum; W E Thiessen
Journal:  J Am Chem Soc       Date:  1977-02-16       Impact factor: 15.419

2.  Evidence for translation of HPRT enzyme on maternal mRNA in early mouse embryos.

Authors:  M I Harper; M Monk
Journal:  J Embryol Exp Morphol       Date:  1983-04

3.  alpha-Amanitin-insensitive transcription of mouse beta major-globin 5'-flanking and structural gene sequences correlates with mRNA expression.

Authors:  D P Carlson; J Ross
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

4.  [Ultrastructural lesions produced in hepatic parenchymal cells by phalloidin and alpha-amanitin].

Authors:  L Fiume; R Laschi
Journal:  Sperimentale       Date:  1965 Sep-Oct

5.  Properties of a cell-free system for synthesis of citrus exocortis viroid.

Authors:  R Flores; J S Semancik
Journal:  Proc Natl Acad Sci U S A       Date:  1982-10       Impact factor: 11.205

6.  Structure-toxicity relationships in the amatoxin series. Synthesis of S-deoxy[gamma(R)-hydroxy-Ile3]-amaninamide, its crystal and molecular structure and inhibitory efficiency.

Authors:  G Zanotti; T Wieland; E Benedetti; B Di Blasio; V Pavone; C Pedone
Journal:  Int J Pept Protein Res       Date:  1989-09

Review 7.  [50 years of phalloidine: its discovery, characterization and current and future applications in cell research].

Authors:  T Wieland
Journal:  Naturwissenschaften       Date:  1987-08

Review 8.  Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms.

Authors:  T Wieland; H Faulstich
Journal:  CRC Crit Rev Biochem       Date:  1978-12

9.  Peritrophic membranes and protease activity in the midgut of the malaria mosquito, Anopheles stephensi (Liston) (Insecta: Diptera) under normal and experimental conditions.

Authors:  R Berner; W Rudin; H Hecker
Journal:  J Ultrastruct Res       Date:  1983-05

10.  The transition from maternal to embryonic control in the 2-cell mouse embryo.

Authors:  G Flach; M H Johnson; P R Braude; R A Taylor; V N Bolton
Journal:  EMBO J       Date:  1982       Impact factor: 11.598
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  22 in total

1.  Remodeling of yeast CUP1 chromatin involves activator-dependent repositioning of nucleosomes over the entire gene and flanking sequences.

Authors:  C H Shen; B P Leblanc; J A Alfieri; D J Clark
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

2.  Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution.

Authors:  David A Bushnell; Patrick Cramer; Roger D Kornberg
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-22       Impact factor: 11.205

3.  Resolution of anaphase bridges in cancer cells.

Authors:  Diane R Hoffelder; Li Luo; Nancy A Burke; Simon C Watkins; Susanne M Gollin; William S Saunders
Journal:  Chromosoma       Date:  2004-05-20       Impact factor: 4.316

4.  Peptide bicycles that inhibit the Grb2 SH2 domain.

Authors:  Justin S Quartararo; Pianpian Wu; Joshua A Kritzer
Journal:  Chembiochem       Date:  2012-06-11       Impact factor: 3.164

5.  The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin.

Authors:  Craig D Kaplan; Karl-Magnus Larsson; Roger D Kornberg
Journal:  Mol Cell       Date:  2008-06-06       Impact factor: 17.970

6.  Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis.

Authors:  C Koumenis; A Giaccia
Journal:  Mol Cell Biol       Date:  1997-12       Impact factor: 4.272

7.  Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin.

Authors:  Xiangyang Liu; Lucas Farnung; Christoph Wigge; Patrick Cramer
Journal:  J Biol Chem       Date:  2018-03-17       Impact factor: 5.157

8.  Clustered alpha-amanitin resistance mutations in mouse.

Authors:  M S Bartolomei; J L Corden
Journal:  Mol Gen Genet       Date:  1995-03-20

9.  The Chinese hamster dihydrofolate reductase replication origin decision point follows activation of transcription and suppresses initiation of replication within transcription units.

Authors:  Takayo Sasaki; Sunita Ramanathan; Yukiko Okuno; Chiharu Kumagai; Seemab S Shaikh; David M Gilbert
Journal:  Mol Cell Biol       Date:  2006-02       Impact factor: 4.272

10.  Wingless signaling induces widespread chromatin remodeling of target loci.

Authors:  David S Parker; Yunyun Y Ni; Jinhee L Chang; Jiong Li; Ken M Cadigan
Journal:  Mol Cell Biol       Date:  2007-12-26       Impact factor: 4.272
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