Literature DB >> 9687419

Active efflux of norfloxacin by Bacteroides fragilis.

S Miyamae1, H Nikaido, Y Tanaka, F Yoshimura.   

Abstract

Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.

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Year:  1998        PMID： 9687419      PMCID： PMC105880     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

Authors:  A A Neyfakh; V E Bidnenko; L B Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

2.  Outer membranes of gram-negative bacteria are permeable to steroid probes.

Authors:  P Plésiat; H Nikaido
Journal:  Mol Microbiol       Date:  1992-05       Impact factor: 3.501

3.  Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.

Authors:  N N Baranova; A A Neyfakh
Journal:  Antimicrob Agents Chemother       Date:  1997-06       Impact factor: 5.191

Review 4.  Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.

Authors:  H Nikaido; D G Thanassi
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

5.  Mutants of the Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine.

Authors:  M Ahmed; C M Borsch; A A Neyfakh; S Schuldiner
Journal:  J Biol Chem       Date:  1993-05-25       Impact factor: 5.157

6.  Two complementation groups mediate tetracycline resistance determined by Tn10.

Authors:  M S Curiale; S B Levy
Journal:  J Bacteriol       Date:  1982-07       Impact factor: 3.490

7.  Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.

Authors:  H Yoshida; M Bogaki; S Nakamura; K Ubukata; M Konno
Journal:  J Bacteriol       Date:  1990-12       Impact factor: 3.490

8.  The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.

Authors:  A A Neyfakh
Journal:  Antimicrob Agents Chemother       Date:  1992-02       Impact factor: 5.191

Review 9.  Wound and intraabdominal infections: microbiological considerations and approaches to treatment.

Authors:  R L Nichols; J W Smith
Journal:  Clin Infect Dis       Date:  1993-06       Impact factor: 9.079

10.  Transposition of Tn4351 in Porphyromonas gingivalis.

Authors:  C I Hoover; E Abarbarchuk; C Y Ng; J R Felton
Journal:  Plasmid       Date:  1992-05       Impact factor: 3.466
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  18 in total

Review 1.  Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Authors:  K Poole
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

Review 2.  Structure and function of efflux pumps that confer resistance to drugs.

Authors:  M Ines Borges-Walmsley; Kenneth S McKeegan; Adrian R Walmsley
Journal:  Biochem J       Date:  2003-12-01       Impact factor: 3.857

3.  A resistance-nodulation-cell division family xenobiotic efflux pump in an obligate anaerobe, Porphyromonas gingivalis.

Authors:  Takeshi Ikeda; Fuminobu Yoshimura
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

4.  Role of topoisomerase mutations and efflux in fluoroquinolone resistance of Bacteroides fragilis clinical isolates and laboratory mutants.

Authors:  Vito Ricci; Marnie L Peterson; John C Rotschafer; Hannah Wexler; Laura J V Piddock
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191

5.  Efflux pump overexpression in multiple-antibiotic-resistant mutants of Bacteroides fragilis.

Authors:  Lilian Pumbwe; Daniel Glass; Hannah M Wexler
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

6.  Genetic determinant of intrinsic quinolone resistance in Fusobacterium canifelinum.

Authors:  Georg Conrads; Diane M Citron; Ellie J C Goldstein
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

7.  Roles of gyrA mutations in resistance of clinical isolates and in vitro mutants of Bacteroides fragilis to the new fluoroquinolone trovafloxacin.

Authors:  R Bachoual; L Dubreuil; C J Soussy; J Tankovic
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

8.  Molecular cloning of the gyrA and gyrB genes of Bacteroides fragilis encoding DNA gyrase.

Authors:  Y Onodera; K Sato
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

9.  gyrA mutations associated with quinolone resistance in Bacteroides fragilis group strains.

Authors:  H Oh; N El Amin; T Davies; P C Appelbaum; C Edlund
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

Review 10.  Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.

Authors:  David C Hooper; George A Jacoby
Journal:  Cold Spring Harb Perspect Med       Date:  2016-09-01       Impact factor: 6.915
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