Literature DB >> 1605617

The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.

A A Neyfakh1.   

Abstract

The Bacillus subtilis multidrug efflux transporter Bmr demonstrates 44% amino acid sequence identity with a product of the Staphylococcus aureus gene norA, which is responsible for clinically relevant resistance to fluoroquinolones. We show here that overexpression of bmr in B. subtilis provides strong resistance to fluoroquinolones that can be reversed by reserpine, an inhibitor of Bmr.

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Year:  1992        PMID： 1605617      PMCID： PMC188464          DOI： 10.1128/AAC.36.2.484

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

Authors:  A A Neyfakh; V E Bidnenko; L B Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

Review 2.  Accumulation of biological amines into chromaffin granules: a model for hormone and neurotransmitter transport.

Authors:  R G Johnson
Journal:  Physiol Rev       Date:  1988-01       Impact factor: 37.312

3.  Endogenous active efflux of norfloxacin in susceptible Escherichia coli.

Authors:  S P Cohen; D C Hooper; J S Wolfson; K S Souza; L M McMurry; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1988-08       Impact factor: 5.191

4.  Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.

Authors:  H Yoshida; M Bogaki; S Nakamura; K Ubukata; M Konno
Journal:  J Bacteriol       Date:  1990-12       Impact factor: 3.490

5.  Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine.

Authors:  W T Beck; M C Cirtain; C J Glover; R L Felsted; A R Safa
Journal:  Biochem Biophys Res Commun       Date:  1988-06-30       Impact factor: 3.575
  5 in total
  50 in total

Review 1.  Molecular properties of bacterial multidrug transporters.

Authors:  M Putman; H W van Veen; W N Konings
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

Review 2.  Molecular detection of antimicrobial resistance.

Authors:  A C Fluit; M R Visser; F J Schmitz
Journal:  Clin Microbiol Rev       Date:  2001-10       Impact factor: 26.132

Review 3.  Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria.

Authors:  K Poole
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

Review 4.  Structure and function of efflux pumps that confer resistance to drugs.

Authors:  M Ines Borges-Walmsley; Kenneth S McKeegan; Adrian R Walmsley
Journal:  Biochem J       Date:  2003-12-01       Impact factor: 3.857

Review 5.  Active efflux mechanisms for antimicrobial resistance.

Authors:  S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1992-04       Impact factor: 5.191

6.  A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway.

Authors:  Kathy K Wang; Laura K Stone; Tami D Lieberman; Michal Shavit; Timor Baasov; Roy Kishony
Journal:  Mol Biol Evol       Date:  2015-11-03       Impact factor: 16.240

Review 7.  Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors:  Laura J V Piddock
Journal:  Clin Microbiol Rev       Date:  2006-04       Impact factor: 26.132

8.  The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants.

Authors:  I T Paulsen; T G Littlejohn; P Rådström; L Sundström; O Sköld; G Swedberg; R A Skurray
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

9.  Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus.

Authors:  Que Chi Truong-Bolduc; Xiamei Zhang; David C Hooper
Journal:  J Bacteriol       Date:  2003-05       Impact factor: 3.490

Review 10.  Mechanisms of resistance to quinolones.

Authors:  E Cambau; L Gutmann
Journal:  Drugs       Date:  1993       Impact factor: 9.546
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