Literature DB >> 16940115

Efflux pump overexpression in multiple-antibiotic-resistant mutants of Bacteroides fragilis.

Lilian Pumbwe1, Daniel Glass, Hannah M Wexler.   

Abstract

Multidrug-resistant mutants of a wild-type Bacteroides fragilis strain (strain ADB77) and a quadruple resistance nodulation division family efflux pump deletion mutant (ADB77 Delta bmeB1 Delta bmeB3 Delta bmeB12 Delta bmeB15) were selected with antimicrobials. Ampicillin, doripenem, imipenem, levofloxacin, and metronidazole selected for mutants from both strains; cefoxitin selected for mutants from strain ADB77 only; and sodium dodecyl sulfate selected mutants from ADB77Delta bmeB1 Delta bmeB3 Delta bmeB12 Delta bmeB15 only. The mutants overexpressed one or more efflux pumps.

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Year:  2006        PMID： 16940115      PMCID： PMC1563565          DOI： 10.1128/AAC.00141-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Role of topoisomerase mutations and efflux in fluoroquinolone resistance of Bacteroides fragilis clinical isolates and laboratory mutants.

Authors:  Vito Ricci; Marnie L Peterson; John C Rotschafer; Hannah Wexler; Laura J V Piddock
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191

2.  Bacteroides fragilis BmeABC efflux systems additively confer intrinsic antimicrobial resistance.

Authors:  Lilian Pumbwe; Ohmi Ueda; Fuminobu Yoshimura; Abraham Chang; Rachel L Smith; Hannah M Wexler
Journal:  J Antimicrob Chemother       Date:  2006-06-06       Impact factor: 5.790

3.  The biocide triclosan selects Stenotrophomonas maltophilia mutants that overproduce the SmeDEF multidrug efflux pump.

Authors:  Patricia Sanchez; Eduardo Moreno; Jose L Martinez
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

4.  Comparison of spiral gradient and conventional agar dilution for susceptibility testing of anaerobic bacteria.

Authors:  H M Wexler; E Molitoris; F Jashnian; S M Finegold
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

5.  Use of genome-wide expression profiling and mutagenesis to study the intestinal lifestyle of Campylobacter jejuni.

Authors:  Alain Stintzi; Denver Marlow; Kiran Palyada; Hemant Naikare; Roger Panciera; Lisa Whitworth; Cyril Clarke
Journal:  Infect Immun       Date:  2005-03       Impact factor: 3.441

6.  Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli.

Authors:  W V Kern; M Oethinger; A S Jellen-Ritter; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

7.  Analysis of antibiotic resistance gene expression in Pseudomonas aeruginosa by quantitative real-time-PCR.

Authors:  Jean-Luc Dumas; Christian van Delden; Karl Perron; Thilo Köhler
Journal:  FEMS Microbiol Lett       Date:  2006-01       Impact factor: 2.742

8.  Sixteen homologs of the mex-type multidrug resistance efflux pump in Bacteroides fragilis.

Authors:  Ohmi Ueda; Hannah M Wexler; Kaname Hirai; Yukinaga Shibata; Fuminobu Yoshimura; Setsuo Fujimura
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

9.  Clinical significance of overexpression of multiple RND-family efflux pumps in Bacteroides fragilis isolates.

Authors:  Lilian Pumbwe; Abraham Chang; Rachel L Smith; Hannah M Wexler
Journal:  J Antimicrob Chemother       Date:  2006-07-12       Impact factor: 5.790

10.  Active efflux of norfloxacin by Bacteroides fragilis.

Authors:  S Miyamae; H Nikaido; Y Tanaka; F Yoshimura
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191
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  19 in total

Review 1.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

Review 2.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

3.  In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds.

Authors:  Ellie J C Goldstein; Diane M Citron; C Vreni Merriam; Yumi A Warren; Kerin L Tyrrell; Helen T Fernandez
Journal:  Antimicrob Agents Chemother       Date:  2007-12-10       Impact factor: 5.191

4.  Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity.

Authors:  Yukiko Miyamoto; Jaroslaw Kalisiak; Keith Korthals; Tineke Lauwaet; Dae Young Cheung; Ricardo Lozano; Eduardo R Cobo; Peter Upcroft; Jacqueline A Upcroft; Douglas E Berg; Frances D Gillin; Valery V Fokin; K Barry Sharpless; Lars Eckmann
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-07       Impact factor: 11.205

Review 5.  Doripenem: a review of its use in the treatment of bacterial infections.

Authors:  Susan J Keam
Journal:  Drugs       Date:  2008       Impact factor: 9.546

6.  Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae.

Authors:  C Alauzet; F Mory; C Teyssier; H Hallage; J P Carlier; G Grollier; A Lozniewski
Journal:  Antimicrob Agents Chemother       Date:  2009-10-05       Impact factor: 5.191

Review 7.  Bacteroides: the good, the bad, and the nitty-gritty.

Authors:  Hannah M Wexler
Journal:  Clin Microbiol Rev       Date:  2007-10       Impact factor: 26.132

8.  Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.

Authors:  Ritu Pasrija; Sneh Lata Panwar; Rajendra Prasad
Journal:  Antimicrob Agents Chemother       Date:  2007-12-03       Impact factor: 5.191

9.  Characteristics of doripenem: a new broad-spectrum antibiotic.

Authors:  Francisco Alvarez-Lerma; Santiago Grau; Olivia Ferrández
Journal:  Drug Des Devel Ther       Date:  2009-09-21       Impact factor: 4.162

10.  Efflux Pump Overexpression Profiling in Acinetobacter baumannii and Study of New 1-(1-Naphthylmethyl)-Piperazine Analogs as Potential Efflux Inhibitors.

Authors:  Morgane Choquet; Elodie Lohou; Etienne Pair; Pascal Sonnet; Catherine Mullié
Journal:  Antimicrob Agents Chemother       Date:  2021-08-17       Impact factor: 5.191
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