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Literature DB >> 15616329

Genetic determinant of intrinsic quinolone resistance in Fusobacterium canifelinum.

Georg Conrads¹, Diane M Citron, Ellie J C Goldstein.

Abstract

Fourteen fluoroquinolone-resistant fusobacterial strains, originating from cats or dogs, were characterized by sequencing of the 16S-23S and 16S rRNA genes and DNA-DNA hybridization and were described as a new species, Fusobacterium canifelinum. All of the strains are intrinsically resistant (MIC, >4 g/ml) to levofloxacin and other fluoroquinolones. Compared to the quinolone resistance-determining region (gyrA) of the susceptible relative F. nucleatum, we found that Ser79 was replaced with leucine and Gly83 was replaced with arginine.

Entities: Chemical Mutation Species

Mesh：

Substances：

Year: 2005 PMID： 15616329 PMCID： PMC538909 DOI： 10.1128/AAC.49.1.434-437.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

22 in total

Review 1. In vitro antibacterial activity and pharmacodynamics of new quinolones.

Authors: A Dalhoff; F-J Schmitz
Journal: Eur J Clin Microbiol Infect Dis Date: 2003-04-01 Impact factor: 3.267

2. Trovafloxacin compared with levofloxacin, ofloxacin, ciprofloxacin, azithromycin and clarithromycin against unusual aerobic and anaerobic human and animal bite-wound pathogens.

Authors: E J Goldstein; D M Citron; M Hudspeth; S Hunt Gerardo; C V Merriam
Journal: J Antimicrob Chemother Date: 1998-03 Impact factor: 5.790

3. Clinical Differences in Patients Infected with Fusobacterium and Antimicrobial Susceptibility of Fusobacterium Isolates Recovered at a Tertiary-Care Hospital in Korea.

Authors: Myungsook Kim; Shin Young Yun; Yunhee Lee; Hyukmin Lee; Dongeun Yong; Kyungwon Lee
Journal: Ann Lab Med Date: 2022-03-01 Impact factor: 3.464

3 in total

Genetic determinant of intrinsic quinolone resistance in Fusobacterium canifelinum.

Review 1. In vitro antibacterial activity and pharmacodynamics of new quinolones.

2. Trovafloxacin compared with levofloxacin, ofloxacin, ciprofloxacin, azithromycin and clarithromycin against unusual aerobic and anaerobic human and animal bite-wound pathogens.

3. Antimicrobial susceptibility of non-Bacteroides fragilis group anaerobic Gram-negative bacilli in Europe.

4. Activities of garenoxacin (BMS-284756) and other agents against anaerobic clinical isolates.

5. Antecedent use of fluoroquinolones is associated with resistance to moxifloxacin in Clostridium difficile.

6. Mechanism of quinolone resistance in anaerobic bacteria.

7. Active efflux of norfloxacin by Bacteroides fragilis.

8. Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus.

9. Fusobacterium canifelinum sp. nov., from the oral cavity of cats and dogs.

10. [Antibacterial activity of new-quinolone and macrolide antibiotics against oral bacteria].

Review 1. Antianaerobic antimicrobials: spectrum and susceptibility testing.

Review 2. Microbiology of animal bite wound infections.

3. Clinical Differences in Patients Infected with Fusobacterium and Antimicrobial Susceptibility of Fusobacterium Isolates Recovered at a Tertiary-Care Hospital in Korea.