Literature DB >> 9661034

Energy-dependent accumulation of fluoroquinolones in quinolone-resistant Klebsiella pneumoniae strains.

L Martínez-Martínez1, I García, S Ballesta, V J Benedí, S Hernández-Allés, A Pascual.   

Abstract

The intracellular accumulation of norfloxacin and pefloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents.

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Year:  1998        PMID： 9661034      PMCID： PMC105696     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  Multiantibiotic resistance caused by active drug extrusion in Pseudomonas aeruginosa and other gram-negative bacteria.

Authors:  T Nakae
Journal:  Microbiologia       Date:  1997-09

2.  In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections.

Authors:  T Deguchi; T Kawamura; M Yasuda; M Nakano; H Fukuda; H Kato; N Kato; Y Okano; Y Kawada
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

3.  Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae.

Authors:  T Deguchi; A Fukuoka; M Yasuda; M Nakano; S Ozeki; E Kanematsu; Y Nishino; S Ishihara; Y Ban; Y Kawada
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

4.  Genetic and biochemical characterization of norfloxacin resistance in Escherichia coli.

Authors:  D C Hooper; J S Wolfson; K S Souza; C Tung; G L McHugh; M N Swartz
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

5.  Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV.

Authors:  D M Breines; S Ouabdesselam; E Y Ng; J Tankovic; S Shah; C J Soussy; D C Hooper
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

6.  Multidrug resistance in Klebsiella pneumoniae: a novel gene, ramA, confers a multidrug resistance phenotype in Escherichia coli.

Authors:  Anthony M George; Ruth M Hall; H W Stokes
Journal:  Microbiology (Reading)       Date:  1995-08       Impact factor: 2.777

7.  Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli.

Authors:  J Vila; J Ruiz; P Goñi; M T De Anta
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

8.  In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum-cephalosporins.

Authors:  L Martínez-Martínez; S Hernández-Allés; S Albertí; J M Tomás; V J Benedi; G A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

9.  Selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes.

Authors:  C C Sanders; W E Sanders; R V Goering; V Werner
Journal:  Antimicrob Agents Chemother       Date:  1984-12       Impact factor: 5.191

10.  A porin from Klebsiella pneumoniae: sequence homology, three-dimensional model, and complement binding.

Authors:  S Albertí; F Rodríquez-Quiñones; T Schirmer; G Rummel; J M Tomás; J P Rosenbusch; V J Benedí
Journal:  Infect Immun       Date:  1995-03       Impact factor: 3.441
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  13 in total

Review 1.  Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Authors:  K Poole
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

2.  Fluoroquinolone resistance in Haemophilus influenzae is associated with hypermutability.

Authors:  María Pérez-Vázquez; Federico Román; Silvia García-Cobos; José Campos
Journal:  Antimicrob Agents Chemother       Date:  2007-02-05       Impact factor: 5.191

3.  Quinolones sensitize gram-negative bacteria to antimicrobial peptides.

Authors:  Miguel A Campos; Pau Morey; José A Bengoechea
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

4.  Patterns of resistance associated with integrons, the extended-spectrum beta-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak.

Authors:  Paul Gruteke; Wil Goessens; Jan Van Gils; Paul Peerbooms; Nicole Lemmens-Den Toom; Marga Van Santen-Verheuvel; Alex Van Belkum; Henri Verbrugh
Journal:  J Clin Microbiol       Date:  2003-03       Impact factor: 5.948

5.  Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production.

Authors:  Luis Martínez-Martínez; Alvaro Pascual; María del Carmen Conejo; Isabel García; Providencia Joyanes; Antonio Doménech-Sánchez; Vicente Javier Benedí
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

6.  Prediction of Fluoroquinolone Susceptibility Directly from Whole-Genome Sequence Data by Using Liquid Chromatography-Tandem Mass Spectrometry To Identify Mutant Genotypes.

Authors:  Wan Ahmad Kamil Wan Nur Ismah; Yuiko Takebayashi; Jacqueline Findlay; Kate J Heesom; Juan-Carlos Jiménez-Castellanos; Jay Zhang; Lee Graham; Karen Bowker; O Martin Williams; Alasdair P MacGowan; Matthew B Avison
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

7.  Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.

Authors:  T Schneiders; S G B Amyes; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

8.  Role of Klebsiella pneumoniae OmpK35 porin in antimicrobial resistance.

Authors:  Antonio Doménech-Sánchez; Luis Martínez-Martínez; Santiago Hernández-Allés; María del Carmen Conejo; Alvaro Pascual; Juan M Tomás; Sebastián Albertí; Vicente Javier Benedí
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

9.  Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence.

Authors:  Emma Padilla; Enrique Llobet; Antonio Doménech-Sánchez; Luis Martínez-Martínez; José Antonio Bengoechea; Sebastián Albertí
Journal:  Antimicrob Agents Chemother       Date:  2009-10-26       Impact factor: 5.191

10.  Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China.

Authors:  Yingmei Fu; Lishuang Guo; Yan Xu; Wenli Zhang; Jiaao Gu; Jianfeng Xu; Xiaobei Chen; Yuehui Zhao; Jiayu Ma; Xinghan Liu; Fengmin Zhang
Journal:  Antimicrob Agents Chemother       Date:  2008-05-27       Impact factor: 5.191
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