Literature DB >> 17283196

Fluoroquinolone resistance in Haemophilus influenzae is associated with hypermutability.

María Pérez-Vázquez1, Federico Román, Silvia García-Cobos, José Campos.   

Abstract

Forty-three percent (12/28) of ciprofloxacin (CIP)-nonsusceptible respiratory isolates of Haemophilus influenzae were hypermutable, compared with 8.5% (3/35) in the CIP-susceptible control group (P=0.002). CIP-nonsusceptible mutants were obtained with hypermutable strains only; these mutants developed three resistance mechanisms in a step-by-step process: target modifications, loss of a porin protein, and increased efflux.

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Year:  2007        PMID： 17283196      PMCID： PMC1855460          DOI： 10.1128/AAC.01437-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Mutator bacteria as a risk factor in treatment of infectious diseases.

Authors:  Antoine Giraud; Ivan Matic; Miroslav Radman; Michel Fons; François Taddei
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

2.  Hypermutation as a factor contributing to the acquisition of antimicrobial resistance.

Authors:  Jesús Blázquez
Journal:  Clin Infect Dis       Date:  2003-09-30       Impact factor: 9.079

3.  Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin.

Authors:  Frank S Kaczmarek; Thomas D Gootz; Fadia Dib-Hajj; Wenchi Shang; Shawn Hallowell; Melissa Cronan
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

4.  Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production.

Authors:  Luis Martínez-Martínez; Alvaro Pascual; María del Carmen Conejo; Isabel García; Providencia Joyanes; Antonio Doménech-Sánchez; Vicente Javier Benedí
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

5.  Dynamics of long-term colonization of respiratory tract by Haemophilus influenzae in cystic fibrosis patients shows a marked increase in hypermutable strains.

Authors:  Federico Román; Rafael Cantón; María Pérez-Vázquez; Fernando Baquero; José Campos
Journal:  J Clin Microbiol       Date:  2004-04       Impact factor: 5.948

6.  Laboratory detection of Haemophilus influenzae with decreased susceptibility to nalidixic acid, ciprofloxacin, levofloxacin, and moxifloxacin due to GyrA and ParC mutations.

Authors:  María Pérez-Vázquez; Federico Román; Belén Aracil; Rafael Cantón; José Campos
Journal:  J Clin Microbiol       Date:  2004-03       Impact factor: 5.948

7.  In vitro activities of garenoxacin (BMS-284756) against Haemophilus influenzae isolates with different fluoroquinolone susceptibilities.

Authors:  María Pérez-Vázquez; Federico Román; Belen Aracil; Rafael Cantón; José Campos
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

8.  Hypermutable Haemophilus influenzae with mutations in mutS are found in cystic fibrosis sputum.

Authors:  Michael E Watson; Jane L Burns; Arnold L Smith
Journal:  Microbiology       Date:  2004-09       Impact factor: 2.777

9.  Levofloxacin treatment failure in Haemophilus influenzae pneumonia.

Authors:  Teresa Bastida; María Pérez-Vázquez; José Campos; María Cristina Cortés-Lletget; Federico Román; Fe Tubau; Adela G de la Campa; Carles Alonso-Tarrés
Journal:  Emerg Infect Dis       Date:  2003-11       Impact factor: 6.883

10.  Quinolone-resistant Haemophilus influenzae in a long-term care facility: clinical and molecular epidemiology.

Authors:  Jawad Nazir; Carl Urban; Noriel Mariano; Janice Burns; Barbara Tommasulo; Carl Rosenberg; Sorana Segal-Maurer; James J Rahal
Journal:  Clin Infect Dis       Date:  2004-05-12       Impact factor: 9.079
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  10 in total

1.  Melting curve analysis for rapid detection of topoisomerase gene mutations in Haemophilus influenzae.

Authors:  Shigeki Nakamura; Katsunori Yanagihara; Yoshitomo Morinaga; Koichi Izumikawa; Masafumi Seki; Hiroshi Kakeya; Yoshihiro Yamamoto; Shimeru Kamihira; Shigeru Kohno
Journal:  J Clin Microbiol       Date:  2009-01-07       Impact factor: 5.948

Review 2.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

3.  Molecular characterization of fluoroquinolone resistance in nontypeable Haemophilus influenzae clinical isolates.

Authors:  Carmen Puig; José Manuel Tirado-Vélez; Laura Calatayud; Fe Tubau; Junkal Garmendia; Carmen Ardanuy; Sara Marti; Adela G de la Campa; Josefina Liñares
Journal:  Antimicrob Agents Chemother       Date:  2014-11-10       Impact factor: 5.191

4.  Antimicrobial resistance among Haemophilus influenzae isolates responsible for lower respiratory tract infections in Poland, 2005-2019.

Authors:  Marlena Kiedrowska; Weronika Jasmina Foryś; Agnieszka Gołębiewska; Izabela Waśko; Patrycja Ronkiewicz; Alicja Kuch; Izabela Wróbel-Pawelczyk; Michał Wroczyński; Waleria Hryniewicz; Anna Skoczyńska
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2022-05-18       Impact factor: 3.267

5.  In Vitro Derivation of Fluoroquinolone-Resistant Mutants from Multiple Lineages of Haemophilus influenzae and Identification of Mutations Associated with Fluoroquinolone Resistance.

Authors:  Hiroyuki Honda; Toyotaka Sato; Masaaki Shinagawa; Yukari Fukushima; Chie Nakajima; Yasuhiko Suzuki; Koji Kuronuma; Satoshi Takahashi; Hiroki Takahashi; Shin-Ichi Yokota
Journal:  Antimicrob Agents Chemother       Date:  2020-01-27       Impact factor: 5.191

6.  Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone resistance-determining regions.

Authors:  Yoichi Hirakata; Kaori Ohmori; Miwako Mikuriya; Takeshi Saika; Kaoru Matsuzaki; Miyuki Hasegawa; Masumitsu Hatta; Natsuo Yamamoto; Hiroyuki Kunishima; Hisakazu Yano; Miho Kitagawa; Kazuaki Arai; Kazuyoshi Kawakami; Intetsu Kobayashi; Ronald N Jones; Shigeru Kohno; Keizo Yamaguchi; Mitsuo Kaku
Journal:  Antimicrob Agents Chemother       Date:  2009-08-03       Impact factor: 5.191

7.  Emergence of fluoroquinolone-resistant Haemophilus influenzae strains among elderly patients but not among children.

Authors:  Shin-ichi Yokota; Yasuo Ohkoshi; Kiyoshi Sato; Nobuhiro Fujii
Journal:  J Clin Microbiol       Date:  2007-10-31       Impact factor: 5.948

8.  Reduced levofloxacin susceptibility in clinical respiratory isolates of Haemophilus influenzae is not yet associated with mutations in the DNA gyrase and topoisomerase II genes in Korea.

Authors:  In-Suk Kim; Nam Yong Lee; Sunjoo Kim; Chang-Seok Ki; Sun-Hee Kim
Journal:  Yonsei Med J       Date:  2011-01       Impact factor: 2.759

9.  Levofloxacin-resistant haemophilus influenzae, Taiwan, 2004-2010.

Authors:  Shu-Chen Kuo; Pei-Chen Chen; Yih-Ru Shiau; Hui-Ying Wang; Jui-Fen Lai; Wen Huang; Tsai-Ling Yang Lauderdale
Journal:  Emerg Infect Dis       Date:  2014-08       Impact factor: 6.883

Review 10.  [Microbiological diagnosis of bronchopulmonary colonization-infection in cystic fibrosis].

Authors:  Antonio Oliver; Teresa Alarcón; Estrella Caballero; Rafael Cantón
Journal:  Enferm Infecc Microbiol Clin       Date:  2009-02-20       Impact factor: 1.731
  10 in total

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