Literature DB >> 14506051

Role of Klebsiella pneumoniae OmpK35 porin in antimicrobial resistance.

Antonio Doménech-Sánchez1, Luis Martínez-Martínez, Santiago Hernández-Allés, María del Carmen Conejo, Alvaro Pascual, Juan M Tomás, Sebastián Albertí, Vicente Javier Benedí.   

Abstract

OmpK35 from Klebsiella pneumoniae is the homologue of Escherichia coli OmpF porin. Expression of OmpK35 in K. pneumoniae strain CSUB10R (lacking both OmpK35 and OmpK36) decreased the MICs of cephalosporins and meropenem > or = 128-fold and decreased the MICs of imipenem, ciprofloxacin, and chloramphenicol > or = 8-fold. MIC reductions by OmpK35 were 4 times (cefepime), 8 times (cefotetan, cefotaxime, and cefpirome), or 128 times (ceftazidime) higher than those caused by OmpK36, but the MICs were similar or 1 dilution lower for other evaluated agents.

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Year:  2003        PMID： 14506051      PMCID： PMC201126          DOI： 10.1128/AAC.47.10.3332-3335.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Is OmpK35 specific for ceftazadime penetration?

Authors:  L K Siu
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

2.  Relationship between outer membrane alterations and susceptibility to antimicrobial agents in isogenic strains of Klebsiella pneumoniae.

Authors:  S Hernández-Allés; M d Conejo; A Pascual; J M Tomás; V J Benedí; L Martínez-Martínez
Journal:  J Antimicrob Chemother       Date:  2000-08       Impact factor: 5.790

3.  Crystal structures explain functional properties of two E. coli porins.

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Authors:  R F Wang; S R Kushner
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5.  Porin expression in clinical isolates of Klebsiella pneumoniae.

Authors:  Santiago Hernández-Allés; Sebastián Albertí; Dolores Álvarez; Antonio Doménech-Sánchez; Luis Martínez-Martínez; José Gil; Juan M Tomás; Vicente J Benedí
Journal:  Microbiology       Date:  1999-03       Impact factor: 2.777

6.  Identification and characterization of a new porin gene of Klebsiella pneumoniae: its role in beta-lactam antibiotic resistance.

Authors:  A Doménech-Sánchez; S Hernández-Allés; L Martínez-Martínez; V J Benedí; S Albertí
Journal:  J Bacteriol       Date:  1999-05       Impact factor: 3.490

7.  Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production.

Authors:  Luis Martínez-Martínez; Alvaro Pascual; María del Carmen Conejo; Isabel García; Providencia Joyanes; Antonio Doménech-Sánchez; Vicente Javier Benedí
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

8.  Construction of broad-host-range cosmid cloning vectors: identification of genes necessary for growth of Methylobacterium organophilum on methanol.

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Journal:  J Bacteriol       Date:  1985-03       Impact factor: 3.490

9.  Role of capsule and O antigen in resistance of Klebsiella pneumoniae to serum bactericidal activity.

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  48 in total

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2.  Porin Loss Impacts the Host Inflammatory Response to Outer Membrane Vesicles of Klebsiella pneumoniae.

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3.  Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence.

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4.  Prevalence and role of efflux pump activity in ciprofloxacin resistance in clinical isolates of Klebsiella pneumoniae.

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5.  Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides.

Authors:  Enrique Llobet; Catalina March; Paloma Giménez; José A Bengoechea
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6.  Large oligoclonal outbreak due to Klebsiella pneumoniae ST14 and ST26 producing the FOX-7 AmpC β-lactamase in a neonatal intensive care unit.

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Journal:  J Clin Microbiol       Date:  2013-10-02       Impact factor: 5.948

7.  Contribution of β-lactamases and porin proteins OmpK35 and OmpK36 to carbapenem resistance in clinical isolates of KPC-2-producing Klebsiella pneumoniae.

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8.  Role of Klebsiella pneumoniae LamB Porin in antimicrobial resistance.

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9.  Doripenem, gentamicin, and colistin, alone and in combinations, against gentamicin-susceptible, KPC-producing Klebsiella pneumoniae strains with various ompK36 genotypes.

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10.  Combined porin loss and extended spectrum beta-lactamase production is associated with an increasing imipenem minimal inhibitory concentration in clinical Klebsiella pneumoniae strains.

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