Literature DB >> 9056017

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae.

T Deguchi1, A Fukuoka, M Yasuda, M Nakano, S Ozeki, E Kanematsu, Y Nishino, S Ishihara, Y Ban, Y Kawada.   

Abstract

We determined a partial sequence of the Klebsiella pneumoniae parC gene, including the region analogous to the quinolone resistance-determining region of the Escherichia coli gyrA gene, and examined 26 clinical strains of K. pneumoniae for an association of alterations in GyrA and ParC with susceptibilities to quinolones. The study suggests that in K. pneumoniae DNA gyrase is a primary target of quinolones and that ParC alterations play a complementary role in the development of higher-level fluoroquinolone resistance.

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Year:  1997        PMID： 9056017      PMCID： PMC163775     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  New topoisomerase essential for chromosome segregation in E. coli.

Authors:  J Kato; Y Nishimura; R Imamura; H Niki; S Hiraga; H Suzuki
Journal:  Cell       Date:  1990-10-19       Impact factor: 41.582

2.  Cloning and sequence analysis of gyrA gene of Klebsiella pneumoniae.

Authors:  G P Dimri; H K Das
Journal:  Nucleic Acids Res       Date:  1990-01-11       Impact factor: 16.971

3.  Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus.

Authors:  J Yamagishi; T Kojima; Y Oyamada; K Fujimoto; H Hattori; S Nakamura; M Inoue
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

4.  Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

Authors:  H Yoshida; M Bogaki; M Nakamura; S Nakamura
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

5.  Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.

Authors:  E Y Ng; M Trucksis; D C Hooper
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

6.  Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles.

Authors:  T Deguchi; M Yasuda; M Nakano; S Ozeki; T Ezaki; I Saito; Y Kawada
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

7.  Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene.

Authors:  Y Kumagai; J I Kato; K Hoshino; T Akasaka; K Sato; H Ikeda
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

8.  Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.

Authors:  L Ferrero; B Cameron; B Manse; D Lagneaux; J Crouzet; A Famechon; F Blanche
Journal:  Mol Microbiol       Date:  1994-08       Impact factor: 3.501

9.  Topoisomerase IV is a target of quinolones in Escherichia coli.

Authors:  A B Khodursky; E L Zechiedrich; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205

10.  Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.

Authors:  R J Belland; S G Morrison; C Ison; W M Huang
Journal:  Mol Microbiol       Date:  1994-10       Impact factor: 3.501
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  41 in total

1.  Sequence analysis of the gyrA and parC homologues of a wild-type strain of Vibrio parahaemolyticus and its fluoroquinolone-resistant mutants.

Authors:  J Okuda; E Hayakawa; M Nishibuchi; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

2.  Functional characterization of Brucella melitensis NorMI, an efflux pump belonging to the multidrug and toxic compound extrusion family.

Authors:  Martine Braibant; Laurence Guilloteau; Michel S Zygmunt
Journal:  Antimicrob Agents Chemother       Date:  2002-09       Impact factor: 5.191

3.  Prevalence and role of efflux pump activity in ciprofloxacin resistance in clinical isolates of Klebsiella pneumoniae.

Authors:  S Aathithan; G L French
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-02-01       Impact factor: 3.267

4.  In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections.

Authors:  T Deguchi; T Kawamura; M Yasuda; M Nakano; H Fukuda; H Kato; N Kato; Y Okano; Y Kawada
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

5.  Quinolones sensitize gram-negative bacteria to antimicrobial peptides.

Authors:  Miguel A Campos; Pau Morey; José A Bengoechea
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

6.  Evidence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar typhimurium.

Authors:  E Giraud; A Cloeckaert; D Kerboeuf; E Chaslus-Dancla
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

7.  Diagnosis of quinolone-resistant Coxiella burnetii strains by PCR-RFLP.

Authors:  I Spyridaki; A Psaroulaki; A Aransay; E Scoulica; Y Tselentis
Journal:  J Clin Lab Anal       Date:  2000       Impact factor: 2.352

8.  Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.

Authors:  Somesh Baranwal; Keya Dey; T Ramamurthy; G Balakrish Nair; Manikuntala Kundu
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

9.  Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.

Authors:  T Schneiders; S G B Amyes; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

10.  Sequencing and genetic variation of multidrug resistance plasmids in Klebsiella pneumoniae.

Authors:  Fangqing Zhao; Jie Bai; Jinyu Wu; Jing Liu; Mingming Zhou; Shilin Xia; Shanjin Wang; Xiaoding Yao; Huiguang Yi; Meili Lin; Shengjie Gao; Tieli Zhou; Zuyuan Xu; Yuxin Niu; Qiyu Bao
Journal:  PLoS One       Date:  2010-04-12       Impact factor: 3.240
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