Literature DB >> 18505849

Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China.

Yingmei Fu1, Lishuang Guo, Yan Xu, Wenli Zhang, Jiaao Gu, Jianfeng Xu, Xiaobei Chen, Yuehui Zhao, Jiayu Ma, Xinghan Liu, Fengmin Zhang.   

Abstract

Resistance to ciprofloxacin was detected in 111 (48.1%) isolates of Klebsiella pneumoniae from China. GyrA alterations were identified in the ciprofloxacin-resistant and ciprofloxacin-susceptible isolates. The results, including previously published data, indicate that the single substitution Ser83-->Ile and three types of double mutations at Ser83 and Asp87 were required for ciprofloxacin resistance (P < 0.05).

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Year:  2008        PMID： 18505849      PMCID： PMC2493132          DOI： 10.1128/AAC.00151-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005.

Authors:  Jacob Strahilevitz; Dalia Engelstein; Amos Adler; Violeta Temper; Allon E Moses; Colin Block; Ari Robicsek
Journal:  Antimicrob Agents Chemother       Date:  2007-05-25       Impact factor: 5.191

2.  Increase in MICs of ciprofloxacin in vivo in two closely related clinical isolates of Enterobacter cloacae.

Authors:  Hans-Jörg Linde; Frank Notka; Christine Irtenkauf; Jochen Decker; Jens Wild; Hans-Helmut Niller; Peter Heisig; Norbert Lehn
Journal:  J Antimicrob Chemother       Date:  2002-04       Impact factor: 5.790

3.  Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping.

Authors:  S Brisse; J Verhoef
Journal:  Int J Syst Evol Microbiol       Date:  2001-05       Impact factor: 2.747

4.  Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae.

Authors:  L Martínez-Martínez; A Pascual; S Hernández-Allés; D Alvarez-Díaz; A I Suárez; J Tran; V J Benedí; G A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

5.  Patterns of resistance associated with integrons, the extended-spectrum beta-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak.

Authors:  Paul Gruteke; Wil Goessens; Jan Van Gils; Paul Peerbooms; Nicole Lemmens-Den Toom; Marga Van Santen-Verheuvel; Alex Van Belkum; Henri Verbrugh
Journal:  J Clin Microbiol       Date:  2003-03       Impact factor: 5.948

6.  Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production.

Authors:  Luis Martínez-Martínez; Alvaro Pascual; María del Carmen Conejo; Isabel García; Providencia Joyanes; Antonio Doménech-Sánchez; Vicente Javier Benedí
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

7.  Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli.

Authors:  W V Kern; M Oethinger; A S Jellen-Ritter; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

8.  Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.

Authors:  T Schneiders; S G B Amyes; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

9.  [Mutations in gyrA and gyrB genes among strains of Gram-negative bacilli isolated from Chilean hospitals and their relation with resistance to fluoroquinolones].

Authors:  Mery De la Fuente C; Priscila Dauros S; Helia Bello T; Mariana Domínguez Y; Sergio Mella M; Marcela Sepúlveda A; Raúl Zemelman Z; Gerardo González R
Journal:  Rev Med Chil       Date:  2007-11-15       Impact factor: 0.553

10.  Energy-dependent accumulation of fluoroquinolones in quinolone-resistant Klebsiella pneumoniae strains.

Authors:  L Martínez-Martínez; I García; S Ballesta; V J Benedí; S Hernández-Allés; A Pascual
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191
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  6 in total

1.  Epidemiology, Environmental Risks, Virulence, and Resistance Determinants of Klebsiella pneumoniae From Dairy Cows in Hubei, China.

Authors:  Xiangyun Wu; Jiayi Liu; Jiawei Feng; Muhammad Abu Bakr Shabbir; Yali Feng; Rui Guo; Meifang Zhou; Sulin Hou; Guiqiang Wang; Haihong Hao; Guyue Cheng; Yulian Wang
Journal:  Front Microbiol       Date:  2022-05-04       Impact factor: 6.064

2.  Sequencing and genetic variation of multidrug resistance plasmids in Klebsiella pneumoniae.

Authors:  Fangqing Zhao; Jie Bai; Jinyu Wu; Jing Liu; Mingming Zhou; Shilin Xia; Shanjin Wang; Xiaoding Yao; Huiguang Yi; Meili Lin; Shengjie Gao; Tieli Zhou; Zuyuan Xu; Yuxin Niu; Qiyu Bao
Journal:  PLoS One       Date:  2010-04-12       Impact factor: 3.240

3.  Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.

Authors:  Yingmei Fu; Wenli Zhang; Hong Wang; Song Zhao; Yang Chen; Fanfei Meng; Ying Zhang; Hui Xu; Xiaobei Chen; Fengmin Zhang
Journal:  BMC Infect Dis       Date:  2013-01-07       Impact factor: 3.090

4.  Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms.

Authors:  Pablo Ivan Pereira Ramos; Renata Christina Picão; Luiz Gonzaga Paula de Almeida; Nicholas Costa B Lima; Raquel Girardello; Ana Carolina P Vivan; Danilo E Xavier; Fernando G Barcellos; Marsileni Pelisson; Eliana C Vespero; Claudine Médigue; Ana Tereza Ribeiro de Vasconcelos; Ana Cristina Gales; Marisa Fabiana Nicolás
Journal:  BMC Genomics       Date:  2014-01-22       Impact factor: 3.969

5.  Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.

Authors:  Farah Al-Marzooq; Mohd Yasim Mohd Yusof; Sun Tee Tay
Journal:  Biomed Res Int       Date:  2014-04-10       Impact factor: 3.411

6.  Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens.

Authors:  Neveen M Saleh; Yasmine S Moemen; Sara H Mohamed; Ghady Fathy; Abdullah A S Ahmed; Ahmed A Al-Ghamdi; Sami Ullah; Ibrahim El-Tantawy El Sayed
Journal:  Antibiotics (Basel)       Date:  2022-01-01
  6 in total

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