Literature DB >> 9593173

Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.

G J Alangaden1, B N Kreiswirth, A Aouad, M Khetarpal, F R Igno, S L Moghazeh, E K Manavathu, S A Lerner.   

Abstract

An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

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Year:  1998        PMID： 9593173      PMCID： PMC105813          DOI： 10.1128/AAC.42.5.1295

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  A ribosomal gene mutation in streptomycin-resistant Mycobacterium tuberculosis isolates.

Authors:  J Douglass; L M Steyn
Journal:  J Infect Dis       Date:  1993-06       Impact factor: 5.226

2.  Rapid chemical probing of conformation in 16 S ribosomal RNA and 30 S ribosomal subunits using primer extension.

Authors:  D Moazed; S Stern; H F Noller
Journal:  J Mol Biol       Date:  1986-02-05       Impact factor: 5.469

3.  Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides.

Authors:  A A Beauclerk; E Cundliffe
Journal:  J Mol Biol       Date:  1987-02-20       Impact factor: 5.469

4.  Interaction of antibiotics with functional sites in 16S ribosomal RNA.

Authors:  D Moazed; H F Noller
Journal:  Nature       Date:  1987 Jun 4-10       Impact factor: 49.962

5.  Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: mapping of mutations conferring resistance.

Authors:  A Meier; P Kirschner; F C Bange; U Vogel; E C Böttger
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

6.  Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology.

Authors:  J D van Embden; M D Cave; J T Crawford; J W Dale; K D Eisenach; B Gicquel; P Hermans; C Martin; R McAdam; T M Shinnick
Journal:  J Clin Microbiol       Date:  1993-02       Impact factor: 5.948

7.  Cross-resistant relationships among the aminoglucoside antibiotics in Mycobacterium tuberculosis.

Authors:  M Tsukamura; S Mizuno
Journal:  J Gen Microbiol       Date:  1975-06

8.  The nucleotide sequence of the promoter, 16S rRNA and spacer region of the ribosomal RNA operon of Mycobacterium tuberculosis and comparison with Mycobacterium leprae precursor rRNA.

Authors:  K E Kempsell; Y E Ji; I C Estrada; M J Colston; R A Cox
Journal:  J Gen Microbiol       Date:  1992-08

9.  Amikacin in the treatment of pulmonary tuberculosis.

Authors:  B W Allen; D A Mitchison; Y C Chan; W W Yew; W G Allan; D J Girling
Journal:  Tubercle       Date:  1983-06

10.  Mutations in 16S ribosomal RNA disrupt antibiotic--RNA interactions.

Authors:  E A De Stasio; D Moazed; H F Noller; A E Dahlberg
Journal:  EMBO J       Date:  1989-04       Impact factor: 11.598
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  52 in total

1.  GenoType MTBDRsl for molecular detection of second-line-drug and ethambutol resistance in Mycobacterium tuberculosis strains and clinical samples.

Authors:  A Lacoma; N García-Sierra; C Prat; J Maldonado; J Ruiz-Manzano; L Haba; P Gavin; S Samper; V Ausina; J Domínguez
Journal:  J Clin Microbiol       Date:  2011-11-09       Impact factor: 5.948

2.  Detection by GenoType MTBDRsl test of complex mechanisms of resistance to second-line drugs and ethambutol in multidrug-resistant Mycobacterium tuberculosis complex isolates.

Authors:  Florence Brossier; Nicolas Veziris; Alexandra Aubry; Vincent Jarlier; Wladimir Sougakoff
Journal:  J Clin Microbiol       Date:  2010-03-24       Impact factor: 5.948

3.  Mutation detection and accurate diagnosis of extensively drug-resistant tuberculosis: report from a tertiary care center in India.

Authors:  Kanchan Ajbani; Camilla Rodrigues; Shubhada Shenai; Ajita Mehta
Journal:  J Clin Microbiol       Date:  2011-02-02       Impact factor: 5.948

Review 4.  A balancing act: efflux/influx in mycobacterial drug resistance.

Authors:  G E Louw; R M Warren; N C Gey van Pittius; C R E McEvoy; P D Van Helden; T C Victor
Journal:  Antimicrob Agents Chemother       Date:  2009-05-18       Impact factor: 5.191

5.  Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment.

Authors:  Silke Feuerriegel; Helen S Cox; Nana Zarkua; Hamraev A Karimovich; Kai Braker; Sabine Rüsch-Gerdes; Stefan Niemann
Journal:  Antimicrob Agents Chemother       Date:  2009-05-26       Impact factor: 5.191

6.  Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis.

Authors:  M Analise Zaunbrecher; R David Sikes; Beverly Metchock; Thomas M Shinnick; James E Posey
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-11       Impact factor: 11.205

Review 7.  Clinical implication of novel drug resistance-conferring mutations in resistant tuberculosis.

Authors:  N P Mnyambwa; D-J Kim; E S Ngadaya; R Kazwala; P Petrucka; S G Mfinanga
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2017-06-07       Impact factor: 3.267

8.  Molecular Investigation of Resistance to Second-Line Injectable Drugs in Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis in France.

Authors:  Florence Brossier; Anne Pham; Christine Bernard; Alexandra Aubry; Vincent Jarlier; Nicolas Veziris; Wladimir Sougakoff
Journal:  Antimicrob Agents Chemother       Date:  2017-01-24       Impact factor: 5.191

9.  Aminoglycoside cross-resistance in Mycobacterium tuberculosis due to mutations in the 5' untranslated region of whiB7.

Authors:  Analise Z Reeves; Patricia J Campbell; Razvan Sultana; Seidu Malik; Megan Murray; Bonnie B Plikaytis; Thomas M Shinnick; James E Posey
Journal:  Antimicrob Agents Chemother       Date:  2013-02-04       Impact factor: 5.191

10.  Discordant resistance to kanamycin and amikacin in drug-resistant Mycobacterium tuberculosis.

Authors:  Annika Krüüner; Pontus Jureen; Klavdia Levina; Solomon Ghebremichael; Sven Hoffner
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191
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