Literature DB >> 2953976

Interaction of antibiotics with functional sites in 16S ribosomal RNA.

D Moazed, H F Noller.   

Abstract

Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of action of these antibiotics and for the assignment of functions to specific structural features of 16S rRNA.

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Year:  1987        PMID： 2953976     DOI： 10.1038/327389a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  345 in total

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2.  Programmed ribosomal frameshifting: much ado about knotting!

Authors:  S L Alam; J F Atkins; R F Gesteland
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

3.  Function of the intercistronic region of BRLF1-BZLF1 bicistronic mRNA in translating the zta protein of Epstein-Barr virus.

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Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

4.  Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

Authors:  M Pioletti; F Schlünzen; J Harms; R Zarivach; M Glühmann; H Avila; A Bashan; H Bartels; T Auerbach; C Jacobi; T Hartsch; A Yonath; F Franceschi
Journal:  EMBO J       Date:  2001-04-17       Impact factor: 11.598

5.  Structural basis for selectivity and toxicity of ribosomal antibiotics.

Authors:  E C Böttger; B Springer; T Prammananan; Y Kidan; P Sander
Journal:  EMBO Rep       Date:  2001-04       Impact factor: 8.807

Review 6.  Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.

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Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

7.  RNA aptamers that specifically bind to a 16S ribosomal RNA decoding region construct.

Authors:  J B Tok; J Cho; R R Rando
Journal:  Nucleic Acids Res       Date:  2000-08-01       Impact factor: 16.971

8.  Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame.

Authors:  J L Walewski; T R Keller; D D Stump; A D Branch
Journal:  RNA       Date:  2001-05       Impact factor: 4.942

Review 9.  Ribosomal translocation: one step closer to the molecular mechanism.

Authors:  Shinichiro Shoji; Sarah E Walker; Kurt Fredrick
Journal:  ACS Chem Biol       Date:  2009-02-20       Impact factor: 5.100

Review 10.  Small-Molecule Acetylation by GCN5-Related N-Acetyltransferases in Bacteria.

Authors:  Rachel M Burckhardt; Jorge C Escalante-Semerena
Journal:  Microbiol Mol Biol Rev       Date:  2020-04-15       Impact factor: 11.056
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