Literature DB >> 2441068

Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides.

A A Beauclerk, E Cundliffe.   

Abstract

Methylation of either of two residues (G-1405 or A-1408) within bacterial 16 S ribosomal RNA results in high level resistance to specific combinations of aminoglycoside antibiotics. The product of a gene that originated in Micromonospora purpurea (an actinomycete that produces gentamicin) gives resistance to kanamycin plus gentamicin by converting residue G-1405 to 7-methylguanosine. Resistance to kanamycin plus apramycin results from conversion of residue A-1408 to 1-methyladenosine catalysed by the product of a gene from Streptomyces tenjimariensis.

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Year:  1987        PMID： 2441068     DOI： 10.1016/0022-2836(87)90349-4

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  66 in total

1.  Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations.

Authors:  H Hu; K Ochi
Journal:  Appl Environ Microbiol       Date:  2001-04       Impact factor: 4.792

Review 2.  Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.

Authors:  L P Kotra; J Haddad; S Mobashery
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

3.  Single-base mutations at position 2661 of Escherichia coli 23S rRNA increase efficiency of translational proofreading.

Authors:  P Melançon; W E Tapprich; L Brakier-Gingras
Journal:  J Bacteriol       Date:  1992-12       Impact factor: 3.490

4.  Genetic environments of the rmtA gene in Pseudomonas aeruginosa clinical isolates.

Authors:  Kunikazu Yamane; Yohei Doi; Keiko Yokoyama; Tetsuya Yagi; Hiroshi Kurokawa; Naohiro Shibata; Keigo Shibayama; Haru Kato; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

Review 5.  Avoidance of suicide in antibiotic-producing microbes.

Authors:  Eric Cundliffe; Arnold L Demain
Journal:  J Ind Microbiol Biotechnol       Date:  2010-05-06       Impact factor: 3.346

6.  Ribosomal proteins S7 and L1 are located close to the decoding site of E. coli ribosome--affinity labeling studies with modified tRNAs carrying photoreactive probes attached adjacent to the 3'-end of the anticodon.

Authors:  J Podkowiński; P Górnicki
Journal:  Nucleic Acids Res       Date:  1989-11-11       Impact factor: 16.971

7.  Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.

Authors:  Jun-ichi Wachino; Keigo Shibayama; Hiroshi Kurokawa; Kouji Kimura; Kunikazu Yamane; Satowa Suzuki; Naohiro Shibata; Yasuyoshi Ike; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

8.  Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli.

Authors:  Bruno Périchon; Patrice Courvalin; Marc Galimand
Journal:  Antimicrob Agents Chemother       Date:  2007-04-30       Impact factor: 5.191

9.  Plasmid-mediated 16S rRNA methylases in aminoglycoside-resistant Enterobacteriaceae isolates in Shanghai, China.

Authors:  Qiong Wu; Yibo Zhang; Lizhong Han; Jingyong Sun; Yuxing Ni
Journal:  Antimicrob Agents Chemother       Date:  2008-10-27       Impact factor: 5.191

10.  Structural origins of gentamicin antibiotic action.

Authors:  S Yoshizawa; D Fourmy; J D Puglisi
Journal:  EMBO J       Date:  1998-11-16       Impact factor: 11.598
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