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Literature DB >> 9465042

Is the molten globule a third phase of proteins?

Abstract

The equilibrium properties of proteins are studied by Monte Carlo simulation of two simplified models of protein-like heteropolymers. These models emphasize the polymeric entropy of the fluctuating polypeptide chain. Our calculations suggest a generic phase diagram that contains a thermodynamically distinct "molten globule" state in addition to a rigid native state and a nontrivial unfolded state. The roles of side-chain packing and loop entropy are discussed.

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Year: 1998 PMID： 9465042 PMCID： PMC19058 DOI： 10.1073/pnas.95.4.1490

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

30 in total

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Journal: Nature Date: 1975-02-27 Impact factor: 49.962

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Authors:
Journal: Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics Date: 1993-07

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Authors: E I Shakhnovich
Journal: Fold Des Date: 1996

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Authors: E I Shakhnovich; A M Gutin
Journal: Biophys Chem Date: 1989-11 Impact factor: 2.352

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Authors: E I Shakhnovich; A V Finkelstein
Journal: Biopolymers Date: 1989-10 Impact factor: 2.505

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Authors: E M Boczko; C L Brooks
Journal: Science Date: 1995-07-21 Impact factor: 47.728

8. Monte Carlo simulations of protein folding. I. Lattice model and interaction scheme.

Authors: A Kolinski; J Skolnick
Journal: Proteins Date: 1994-04

9. Packing interactions in the apomyglobin folding intermediate.

Authors: M S Kay; R L Baldwin
Journal: Nat Struct Biol Date: 1996-05

10. The molten globule is a third thermodynamical state of protein molecules.

Authors: O B Ptitsyn; V N Uversky
Journal: FEBS Lett Date: 1994-03-14 Impact factor: 4.124

25 in total

1. What is the role of non-native intermediates of beta-lactoglobulin in protein folding?

Authors: G Chikenji; M Kikuchi
Journal: Proc Natl Acad Sci U S A Date: 2000-12-19 Impact factor: 11.205

2. Folding thermodynamics of model four-strand antiparallel beta-sheet proteins.

Authors: Hyunbum Jang; Carol K Hall; Yaoqi Zhou
Journal: Biophys J Date: 2002-02 Impact factor: 4.033

3. Intermediates can accelerate protein folding.

Authors: C Wagner; T Kiefhaber
Journal: Proc Natl Acad Sci U S A Date: 1999-06-08 Impact factor: 11.205

4. Thermodynamics and stability of a beta-sheet complex: molecular dynamics simulations on simplified off-lattice protein models.

Authors: Hyunbum Jang; Carol K Hall; Yaoqi Zhou
Journal: Protein Sci Date: 2004-01 Impact factor: 6.725

5. Assembly and kinetic folding pathways of a tetrameric beta-sheet complex: molecular dynamics simulations on simplified off-lattice protein models.

Authors: Hyunbum Jang; Carol K Hall; Yaoqi Zhou
Journal: Biophys J Date: 2004-01 Impact factor: 4.033