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Literature DB >> 11121033

What is the role of non-native intermediates of beta-lactoglobulin in protein folding?

Abstract

The mechanism of alpha-->beta transition in folding of beta-lactoglobulin is discussed based on free energy landscape analysis of a long lattice model. It is found that helical propensity of beta-lactoglobulin is driven by conformational entropy and is intrinsically coded in its native structure. We propose a view on a role of folding intermediate, which is "on-pathway" but rich in non-native structures. The present results suggest that the native structure topology plays an important role in alpha-->beta transition.

Mesh：

Substances：
Lactoglobulins

Year: 2000 PMID： 11121033 PMCID： PMC18908 DOI： 10.1073/pnas.97.26.14273

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

Review 1. Go-ing for the prediction of protein folding mechanisms.

Authors: S Takada
Journal: Proc Natl Acad Sci U S A Date: 1999-10-12 Impact factor: 11.205

2. A theoretical search for folding/unfolding nuclei in three-dimensional protein structures.

Authors: O V Galzitskaya; A V Finkelstein
Journal: Proc Natl Acad Sci U S A Date: 1999-09-28 Impact factor: 11.205

3. Studies on protein folding, unfolding and fluctuations by computer simulation. I. The effect of specific amino acid sequence represented by specific inter-unit interactions.

Authors: H Taketomi; Y Ueda; N Gō
Journal: Int J Pept Protein Res Date: 1975

4. Minimum energy compact structures of random sequences of heteropolymers.

Authors:
Journal: Phys Rev Lett Date: 1993-10-11 Impact factor: 9.161

5. Folding pathway of a lattice model for proteins.

Authors: V S Pande; D S Rokhsar
Journal: Proc Natl Acad Sci U S A Date: 1999-02-16 Impact factor: 11.205

6. Testing a new Monte Carlo algorithm for protein folding.

Authors: U Bastolla; H Frauenkron; E Gerstner; P Grassberger; W Nadler
Journal: Proteins Date: 1998-07-01

7. How does a protein fold?

Authors: A Sali; E Shakhnovich; M Karplus
Journal: Nature Date: 1994-05-19 Impact factor: 49.962

8. Is burst hydrophobic collapse necessary for protein folding?

Authors: A M Gutin; V I Abkevich; E I Shakhnovich
Journal: Biochemistry Date: 1995-03-07 Impact factor: 3.162

9. Bovine endothelial cell plasminogen activator inhibitor. Purification and heat activation.

Authors: K Katagiri; K Okada; H Hattori; M Yano
Journal: Eur J Biochem Date: 1988-09-01

10. Non-native alpha-helical intermediate in the refolding of beta-lactoglobulin, a predominantly beta-sheet protein.

Authors: D Hamada; S Segawa; Y Goto
Journal: Nat Struct Biol Date: 1996-10

7 in total

1. Conformational transition states of a beta-hairpin peptide between the ordered and disordered conformations in explicit water.

Authors: Narutoshi Kamiya; Junichi Higo; Haruki Nakamura
Journal: Protein Sci Date: 2002-10 Impact factor: 6.725

2. Lopap, a prothrombin activator from Lonomia obliqua belonging to the lipocalin family: recombinant production, biochemical characterization and structure-function insights.

Authors: Cleyson Valença Reis; Sonia Aparecida Andrade; Oscar Henrique Pereira Ramos; Celso Raul Romero Ramos; Paulo Lee Ho; Isabel de Fátima Correia Batista; Ana Marisa Chudzinski-Tavassi
Journal: Biochem J Date: 2006-09-01 Impact factor: 3.857