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Literature DB >> 9449359

The movement of tRNA through the ribosome.

Abstract

The interaction between tRNA and the ribosome during translation, specifically during elongation, constitutes an example of the motion and adaptability of living molecules. Recent results obtained by cryoelectron microscopy of "naked" ribosomes and ribosomes in functional binding states shine some light on this fundamental life-sustaining process. Inspection of the surface contour of our reconstruction reveals a precise "lock-and-key" fit between the intersubunit space and the tRNA molecule.

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Year: 1998 PMID： 9449359 PMCID： PMC1299411 DOI： 10.1016/S0006-3495(98)77817-8

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

26 in total

1. The 70S Escherichia coli ribosome at 23 A resolution: fitting the ribosomal RNA.

Authors: H Stark; F Mueller; E V Orlova; M Schatz; P Dube; T Erdemir; F Zemlin; R Brimacombe; M van Heel
Journal: Structure Date: 1995-08-15 Impact factor: 5.006

2. Molecular evolution of transfer RNA from two precursor hairpins: implications for the origin of protein synthesis.

Authors: T P Dick; W A Schamel
Journal: J Mol Evol Date: 1995-07 Impact factor: 2.395

3. Direct visualization of A-, P-, and E-site transfer RNAs in the Escherichia coli ribosome.

Authors: R K Agrawal; P Penczek; R A Grassucci; Y Li; A Leith; K H Nierhaus; J Frank
Journal: Science Date: 1996-02-16 Impact factor: 47.728

Review 4. Ribosomes seen through a glass less darkly.

Authors: P B Moore
Journal: Structure Date: 1995-09-15 Impact factor: 5.006

5. Analysis of transient structures by cryo-microscopy combined with rapid mixing of spray droplets.

Authors: J Berriman; N Unwin
Journal: Ultramicroscopy Date: 1994-12 Impact factor: 2.689

6. Topological arrangement of two transfer RNAs on the ribosome. Fluorescence energy transfer measurements between A and P site-bound tRNAphe.

Authors: H Paulsen; J M Robertson; W Wintermeyer
Journal: J Mol Biol Date: 1983-06-25 Impact factor: 5.469

The movement of tRNA through the ribosome.

1. The 70S Escherichia coli ribosome at 23 A resolution: fitting the ribosomal RNA.

2. Molecular evolution of transfer RNA from two precursor hairpins: implications for the origin of protein synthesis.

3. Direct visualization of A-, P-, and E-site transfer RNAs in the Escherichia coli ribosome.

Review 4. Ribosomes seen through a glass less darkly.

5. Analysis of transient structures by cryo-microscopy combined with rapid mixing of spray droplets.

6. Topological arrangement of two transfer RNAs on the ribosome. Fluorescence energy transfer measurements between A and P site-bound tRNAphe.

7. A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome.

8. Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog.

9. Three-dimensional structure of the large ribosomal subunit from Escherichia coli.

10. Three-dimensional reconstruction of the 70S Escherichia coli ribosome in ice: the distribution of ribosomal RNA.

1. Structure and orientation of troponin in the thin filament.

2. Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle.