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Literature DB >> 9294154

Rational protein design: combining theory and experiment.

H W Hellinga¹.

Abstract

Mesh：

Substances：
Proteins

Year: 1997 PMID： 9294154 PMCID： PMC33767 DOI： 10.1073/pnas.94.19.10015

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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28 in total

Review 1. Dominant forces in protein folding.

Authors: K A Dill
Journal: Biochemistry Date: 1990-08-07 Impact factor: 3.162

2. Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin.

Authors: H W Hellinga; J P Caradonna; F M Richards
Journal: J Mol Biol Date: 1991-12-05 Impact factor: 5.469

3. Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry.

Authors: H W Hellinga; F M Richards
Journal: J Mol Biol Date: 1991-12-05 Impact factor: 5.469

4. Computational method for the design of enzymes with altered substrate specificity.

Authors: C Wilson; J E Mace; D A Agard
Journal: J Mol Biol Date: 1991-07-20 Impact factor: 5.469

5. De novo design, expression, and characterization of Felix: a four-helix bundle protein of native-like sequence.

Authors: M H Hecht; J S Richardson; D C Richardson; R C Ogden
Journal: Science Date: 1990-08-24 Impact factor: 47.728

6. The dead-end elimination theorem and its use in protein side-chain positioning.

Authors: J Desmet; M De Maeyer; B Hazes; I Lasters
Journal: Nature Date: 1992-04-09 Impact factor: 49.962

7. Probing the role of packing specificity in protein design.

Authors: B I Dahiyat; S L Mayo
Journal: Proc Natl Acad Sci U S A Date: 1997-09-16 Impact factor: 11.205

8. Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides.

Authors: K Johnsson; R K Allemann; H Widmer; S A Benner
Journal: Nature Date: 1993-10-07 Impact factor: 49.962

9. Molecular technology. Designing proteins and peptides.

Authors: C Pabo
Journal: Nature Date: 1983-01-20 Impact factor: 49.962

10. Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme.

Authors: J H Hurley; W A Baase; B W Matthews
Journal: J Mol Biol Date: 1992-04-20 Impact factor: 5.469

14 in total

1. Contribution of proton linkage to the thermodynamic stability of the major cold-shock protein of Escherichia coli CspA.

Authors: S A Petrosian; G I Makhatadze
Journal: Protein Sci Date: 2000-02 Impact factor: 6.725

Rational protein design: combining theory and experiment.

Review 1. Dominant forces in protein folding.

2. Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin.

3. Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry.

4. Computational method for the design of enzymes with altered substrate specificity.

5. De novo design, expression, and characterization of Felix: a four-helix bundle protein of native-like sequence.

6. The dead-end elimination theorem and its use in protein side-chain positioning.

7. Probing the role of packing specificity in protein design.

8. Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides.

9. Molecular technology. Designing proteins and peptides.

10. Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme.

1. Contribution of proton linkage to the thermodynamic stability of the major cold-shock protein of Escherichia coli CspA.

2. A polar, solvent-exposed residue can be essential for native protein structure.

3. Prediction of amino acid sequence from structure.

4. Structural insights into conformational stability of wild-type and mutant beta1-adrenergic receptor.

5. Systematic placement of structural water molecules for improved scoring of protein-ligand interactions.

6. Insights from molecular dynamics simulations for computational protein design.

7. Evaluation of an inverse molecular design algorithm in a model binding site.

8. Engineering a Hyperstable Yersinia pestis Outer Membrane Protein Ail Using Thermodynamic Design.

9. Trade-off between positive and negative design of protein stability: from lattice models to real proteins.

10. Analysing the origin of long-range interactions in proteins using lattice models.