Literature DB >> 9238000

Phenotypic conversion of drug-resistant bacteria to drug sensitivity.

C Guerrier-Takada1, R Salavati, S Altman.   

Abstract

Plasmids that contain synthetic genes coding for small oligoribonucleotides called external guide sequences (EGSs) have been introduced into strains of Escherichia coli harboring antibiotic resistance genes. The EGSs direct RNase P to cleave the mRNAs transcribed from these genes thereby converting the phenotype of drug-resistant cells to drug sensitivity. Increasing the EGS-to-target mRNA ratio by changing gene copy number or the number of EGSs complementary to different target sites enhances the efficiency of the conversion process. We demonstrate a general method for the efficient phenotypic conversion of drug-resistant bacterial cultures.

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Year:  1997        PMID： 9238000      PMCID： PMC22959          DOI： 10.1073/pnas.94.16.8468

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  External guide sequences for an RNA enzyme.

Authors:  A C Forster; S Altman
Journal:  Science       Date:  1990-08-17       Impact factor: 47.728

2.  Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites.

Authors:  A C Forster; R H Symons
Journal:  Cell       Date:  1987-04-24       Impact factor: 41.582

3.  Different cleavage sites are aligned differently in the active site of M1 RNA, the catalytic subunit of Escherichia coli RNase P.

Authors:  J Kufel; L A Kirsebom
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

4.  Simple RNA enzymes with new and highly specific endoribonuclease activities.

Authors:  J Haseloff; W L Gerlach
Journal:  Nature       Date:  1988-08-18       Impact factor: 49.962

5.  A small catalytic oligoribonucleotide.

Authors:  O C Uhlenbeck
Journal:  Nature       Date:  1987 Aug 13-19       Impact factor: 49.962

6.  Host/vector interactions which affect the viability of recombinant phage lambda clones.

Authors:  K F Wertman; A R Wyman; D Botstein
Journal:  Gene       Date:  1986       Impact factor: 3.688

7.  Mutant drug resistant factors of high transmissibility.

Authors:  E Meynell; N Datta
Journal:  Nature       Date:  1967-05-27       Impact factor: 49.962

8.  Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.

Authors:  F W Studier; B A Moffatt
Journal:  J Mol Biol       Date:  1986-05-05       Impact factor: 5.469

9.  Targeted cleavage of mRNA in vitro by RNase P from Escherichia coli.

Authors:  Y Li; C Guerrier-Takada; S Altman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

10.  The structure of R1drd19: a revised physical map of the plasmid.

Authors:  M Clerget; M Chandler; L Caro
Journal:  Mol Gen Genet       Date:  1981
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  35 in total

1.  Effective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli.

Authors:  P Trang; M Lee; E Nepomuceno; J Kim; H Zhu; F Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

2.  Restoration of vancomycin susceptibility in Enterococcus faecalis by antiresistance determinant gene transfer.

Authors:  C Torres Viera; S Tsiodras; H S Gold; E P Coakley; C Wennersten; G M Eliopoulos; R C Moellering; R T Inouye
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

3.  Inhibition of Escherichia coli viability by external guide sequences complementary to two essential genes.

Authors:  J McKinney; C Guerrier-Takada; D Wesolowski; S Altman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-29       Impact factor: 11.205

4.  Morpholino oligonucleotides do not participate perfectly in standard Watson-Crick complexes with RNA.

Authors:  Gaoping Xiao; Donna Wesolowski; Mina Izadjoo; Sidney Altman
Journal:  RNA       Date:  2010-09-03       Impact factor: 4.942

5.  Chloromycetin resistance of clinically isolated E coli is conversed by using EGS technique to repress the chloromycetin acetyl transferase.

Authors:  Mei-Ying Gao; Chuan-Rui Xu; Ru Chen; Shou-Gui Liu; Jiang-Nan Feng
Journal:  World J Gastroenterol       Date:  2005-12-14       Impact factor: 5.742

Review 6.  Inhibition of gene expression in human cells using RNase P-derived ribozymes and external guide sequences.

Authors:  Kihoon Kim; Fenyong Liu
Journal:  Biochim Biophys Acta       Date:  2007-09-29

7.  Rapid selection of accessible and cleavable sites in RNA by Escherichia coli RNase P and random external guide sequences.

Authors:  Eirik W Lundblad; Gaoping Xiao; Jae-Hyeong Ko; Sidney Altman
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-08       Impact factor: 11.205

8.  Impact of DNA gyrase inhibition by antisense ribozymes on rec A in E. coli.

Authors:  Sainath Rao Shilpakala; Malathi Raghunathan
Journal:  Mol Biol Rep       Date:  2008-11-04       Impact factor: 2.316

9.  Inhibition of aac(6')-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria.

Authors:  Alfonso J C Soler Bistué; Fernando A Martín; Nicolás Vozza; Hongphuc Ha; Jonathan C Joaquín; Angeles Zorreguieta; Marcelo E Tolmasky
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-28       Impact factor: 11.205

10.  Inhibition of expression of virulence genes of Yersinia pestis in Escherichia coli by external guide sequences and RNase P.

Authors:  Jae-hyeong Ko; Mina Izadjoo; Sidney Altman
Journal:  RNA       Date:  2008-06-20       Impact factor: 4.942
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