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Literature DB >> 11181395

Restoration of vancomycin susceptibility in Enterococcus faecalis by antiresistance determinant gene transfer.

C Torres Viera¹, S Tsiodras, H S Gold, E P Coakley, C Wennersten, G M Eliopoulos, R C Moellering, R T Inouye.

Abstract

We assessed the ability of gene transfer to reverse vancomycin resistance in class A (VanA) glycopeptide-resistant Enterococcus faecalis. Recombinant shuttle vectors containing a vanH promoter-vanA antisense gene cassette fully restored vancomycin susceptibility through a combined transcriptional activator binding domain decoy and inducible vanA antisense RNA effect.

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Year: 2001 PMID： 11181395 PMCID： PMC90408 DOI： 10.1128/AAC.45.3.973-975.2001

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

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