Literature DB >> 18567813

Inhibition of expression of virulence genes of Yersinia pestis in Escherichia coli by external guide sequences and RNase P.

Jae-hyeong Ko1, Mina Izadjoo, Sidney Altman.   

Abstract

External guide sequences (EGSs) targeting virulence genes from Yersinia pestis were designed and tested in vitro and in vivo in Escherichia coli. Linear EGSs and M1 RNA-linked EGSs were designed for the yscN and yscS genes that are involved in type III secretion in Y. pestis. RNase P from E. coli cleaves the messages of yscN and yscS in vitro with the cognate EGSs, and the expression of the EGSs resulted in the reduction of the levels of these messages of the virulence genes when those genes were expressed in E. coli.

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Year:  2008        PMID： 18567813      PMCID： PMC2491477          DOI： 10.1261/rna.1120508

Source DB:  PubMed          Journal:  RNA        ISSN： 1355-8382            Impact factor:   4.942


  18 in total

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Authors:  A C Forster; R H Symons
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6.  Preparation and characterization of RNase P from Escherichia coli.

Authors:  M F Baer; J G Arnez; C Guerrier-Takada; A Vioque; S Altman
Journal:  Methods Enzymol       Date:  1990       Impact factor: 1.600

7.  YscN, the putative energizer of the Yersinia Yop secretion machinery.

Authors:  S Woestyn; A Allaoui; P Wattiau; G R Cornelis
Journal:  J Bacteriol       Date:  1994-03       Impact factor: 3.490

8.  Artificial regulation of gene expression in Escherichia coli by RNase P.

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Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

9.  A low-Ca2+ response (LCR) secretion (ysc) locus lies within the lcrB region of the LCR plasmid in Yersinia pestis.

Authors:  K A Fields; G V Plano; S C Straley
Journal:  J Bacteriol       Date:  1994-02       Impact factor: 3.490

10.  Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli.

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  8 in total

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2.  Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum.

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Review 7.  RNase P-Mediated Sequence-Specific Cleavage of RNA by Engineered External Guide Sequences.

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8.  Identification of the Acinetobacter baumannii Ribonuclease P Catalytic Subunit: Cleavage of a Target mRNA in the Presence of an External Guide Sequence.

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  8 in total

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