Literature DB >> 2441261

A small catalytic oligoribonucleotide.

O C Uhlenbeck.   

Abstract

A 19-nucleotide RNA fragment can cause rapid, highly specific cleavage of a 24-nucleotide RNA fragment under physiological conditions. Because each 19-mer can participate in many cleavage reactions, this molecule has all the properties associated with an RNA enzyme.

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Year:  1987        PMID： 2441261     DOI： 10.1038/328596a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  276 in total

1.  High-performance liquid chromatography purification of homogenous-length RNA produced by trans cleavage with a hammerhead ribozyme.

Authors:  T P Shields; E Mollova; L Ste Marie; M R Hansen; A Pardi
Journal:  RNA       Date:  1999-09       Impact factor: 4.942

2.  Rapid kinetic characterization of hammerhead ribozymes by real-time monitoring of fluorescence resonance energy transfer (FRET).

Authors:  K K Singh; R Parwaresch; G Krupp
Journal:  RNA       Date:  1999-10       Impact factor: 4.942

Review 3.  Recent advances in the elucidation of the mechanisms of action of ribozymes.

Authors:  Y Takagi; M Warashina; W J Stec; K Yoshinari; K Taira
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

4.  The virtues of self-binding: high sequence specificity for RNA cleavage by self-processed hammerhead ribozymes.

Authors:  T Ohmichi; E T Kool
Journal:  Nucleic Acids Res       Date:  2000-02-01       Impact factor: 16.971

5.  Inhibition of hepatitis B virus X gene expression by novel DNA enzymes.

Authors:  R Goila; A C Banerjea
Journal:  Biochem J       Date:  2001-02-01       Impact factor: 3.857

6.  Small, efficient hammerhead ribozymes.

Authors:  M J McCall; P Hendry; A A Mir; J Conaty; G Brown; T J Lockett
Journal:  Mol Biotechnol       Date:  2000-01       Impact factor: 2.695

7.  Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3' end can be exported efficiently and specifically to the cytoplasm in mammalian cells.

Authors:  T Kuwabara; M Warashina; S Koseki; M Sano; J Ohkawa; K Nakayama; K Taira
Journal:  Nucleic Acids Res       Date:  2001-07-01       Impact factor: 16.971

8.  Anti-HBV hairpin ribozyme-mediated cleavage of target RNA in vitro.

Authors:  Yu-Hu Song; Ju-Sheng Lin; Nan-Zhi Liu; Xin-Juan Kong; Na Xie; Nan-Xia Wang; You-Xin Jin; Kuo-Huan Liang
Journal:  World J Gastroenterol       Date:  2002-02       Impact factor: 5.742

9.  Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations.

Authors:  J L O'Rear; S Wang; A L Feig; L Beigelman; O C Uhlenbeck; D Herschlag
Journal:  RNA       Date:  2001-04       Impact factor: 4.942

10.  X-ray crystallographic observation of "in-line" and "adjacent" conformations in a bulged self-cleaving RNA/DNA hybrid.

Authors:  V Tereshko; S T Wallace; N Usman; F E Wincott; M Egli
Journal:  RNA       Date:  2001-03       Impact factor: 4.942
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